Transcranial direct current stimulation (tDCS) in a realistic head model

Rosalind Sadleir, Tracy D. Vannorsdall, David J. Schretlen, Barry Gordon

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Distributions of current produced by transcranial direct current stimulation (tDCS) in humans were predicted by a finite-element model representing several individual and collective refinements over prior efforts. A model of the entire human head and brain was made using a finely meshed (1.1×1.1×1.4mm3 voxel) tissue dataset derived from the MRI data set of a normal human brain. The conductivities of ten tissues were simulated (bone, scalp, blood, CSF, muscle, white matter, gray matter, sclera, fat, and cartilage). We then modeled the effect of placing a "stimulating" electrode with a saline-like conductivity over F3, and a similar "reference" electrode over a right supraorbital (RS) location, as well as the complements of these locations, to compare expectations derived from the simulation with experimental data also using these locations in terms of the presence or absence of subjective and objective effects. The sensitivity of the results to changes in conductivity values were examined by varying white matter conductivity over a factor of ten. Our simulations established that high current densities were found directly under the stimulating and reference electrodes, but values of the same order of magnitude occurred in other structures, and many areas of the brain that might be behaviorally active were also subjected to what may be substantial amounts of current. The modeling also suggests that more targeted stimulations might be achieved by different electrode topologies.

Original languageEnglish (US)
Pages (from-to)1310-1318
Number of pages9
JournalNeuroImage
Volume51
Issue number4
DOIs
StatePublished - Jul 2010
Externally publishedYes

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Electrodes
Head
Brain
Sclera
Scalp
Cartilage
Reference Values
Fats
Bone and Bones
Muscles
Transcranial Direct Current Stimulation
White Matter
Datasets

Keywords

  • Finite element model
  • Neuroplasticity
  • tDCS

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Transcranial direct current stimulation (tDCS) in a realistic head model. / Sadleir, Rosalind; Vannorsdall, Tracy D.; Schretlen, David J.; Gordon, Barry.

In: NeuroImage, Vol. 51, No. 4, 07.2010, p. 1310-1318.

Research output: Contribution to journalArticle

Sadleir, Rosalind ; Vannorsdall, Tracy D. ; Schretlen, David J. ; Gordon, Barry. / Transcranial direct current stimulation (tDCS) in a realistic head model. In: NeuroImage. 2010 ; Vol. 51, No. 4. pp. 1310-1318.
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