TY - JOUR
T1 - Toxicity biomarkers among US children compared to a similar cohort in France
T2 - A blinded study measuring urinary porphyrins
AU - Kern, Janet K.
AU - Geier, David A.
AU - Ayzac, Francoise
AU - Adams, James
AU - Mehta, Jyutika A.
AU - Geier, Mark R.
N1 - Funding Information:
This research was funded by a grant from the Autism Research Institute (ARI) and the Brenen Hornstein Autism Research and Education (BHARE) Foundation. The authors wish to acknowledge the help of the parents and children who participated in this study; without their participation this type of investigation would not be possible.
PY - 2011/2
Y1 - 2011/2
N2 - The purpose of this blinded study was to evaluate potential environmental toxicity in a cohort of neurotypical children (n = 28) living in a suburban area of north-central Texas in the United States (US) with a comparable age- and gender-matched cohort of neurotypical children (n = 8) living in a suburban area of southeastern France using urinary porphyrin testing: uroporphyrin (uP), heptacarboxyporphyrin (7cxP), hexacarboxyporphyrin (6cxP), pentacarboxypor-phyrin (5cxP), precoproporphyrin (prcP), and coproporphyrin (cP). Results showed significantly elevated 6cxP, prcP (an atypical, mercury-specific porphy-rin), and cP levels, and increasing trends in 5cxP levels, among neurotypical children in the USA compared to children in France. Data suggest that in US neurotypical children, there is a significantly increased body-burden of mercury (Hg) compared to the body-burden of Hg in the matched neurotypical children in France. The presence of lead contributing to the higher levels of cP also needs to be considered. Further, other factors including genetics can not be completely ruled out.
AB - The purpose of this blinded study was to evaluate potential environmental toxicity in a cohort of neurotypical children (n = 28) living in a suburban area of north-central Texas in the United States (US) with a comparable age- and gender-matched cohort of neurotypical children (n = 8) living in a suburban area of southeastern France using urinary porphyrin testing: uroporphyrin (uP), heptacarboxyporphyrin (7cxP), hexacarboxyporphyrin (6cxP), pentacarboxypor-phyrin (5cxP), precoproporphyrin (prcP), and coproporphyrin (cP). Results showed significantly elevated 6cxP, prcP (an atypical, mercury-specific porphy-rin), and cP levels, and increasing trends in 5cxP levels, among neurotypical children in the USA compared to children in France. Data suggest that in US neurotypical children, there is a significantly increased body-burden of mercury (Hg) compared to the body-burden of Hg in the matched neurotypical children in France. The presence of lead contributing to the higher levels of cP also needs to be considered. Further, other factors including genetics can not be completely ruled out.
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U2 - 10.1080/02772248.2010.508609
DO - 10.1080/02772248.2010.508609
M3 - Article
AN - SCOPUS:78649807579
SN - 0277-2248
VL - 93
SP - 396
EP - 405
JO - Toxicological and Environmental Chemistry
JF - Toxicological and Environmental Chemistry
IS - 2
ER -