TY - GEN
T1 - Towards patient-friendly input signal design for optimized pain treatment interventions
AU - Deshpande, Sunil
AU - Rivera, Daniel
AU - Younger, Jarred
N1 - Funding Information:
⋆ Support for this work has been provided by the Office of Behavioral and Social Sciences Research (OBSSR) of the National Institutes of Health (NIH) and the National Institute on Drug Abuse (NIDA) through grants R21 DA024266 and K25 DA021173. Sunil Deshpande is a doctoral student in electrical engineering at Arizona State.
PY - 2012
Y1 - 2012
N2 - We examine some of the challenges associated with generating input signals for identifying dynamics in pain treatment interventions while imposing "patient-friendly" constraints on the design. Standard clinical trials, while providing some useful information, are not the most suitable vehicle for understanding the dynamic response of dosage changes to participant response. Meanwhile, much of the work in classical input design, even that which incorporates "plant-friendly" considerations, may not result in clinically acceptable trials for human participants. In this paper, we describe some of the issues involved and suggest various approaches (leading ultimately to optimization-based formulations) to obtain input signals with desired spectral properties under time-domain constraints of importance to clinical practice. Numerical examples are shown to illustrate the proposed method with a hypothetical clinical trial of the drug gabapentin for the treatment of neuropathic pain.
AB - We examine some of the challenges associated with generating input signals for identifying dynamics in pain treatment interventions while imposing "patient-friendly" constraints on the design. Standard clinical trials, while providing some useful information, are not the most suitable vehicle for understanding the dynamic response of dosage changes to participant response. Meanwhile, much of the work in classical input design, even that which incorporates "plant-friendly" considerations, may not result in clinically acceptable trials for human participants. In this paper, we describe some of the issues involved and suggest various approaches (leading ultimately to optimization-based formulations) to obtain input signals with desired spectral properties under time-domain constraints of importance to clinical practice. Numerical examples are shown to illustrate the proposed method with a hypothetical clinical trial of the drug gabapentin for the treatment of neuropathic pain.
KW - Biomedical systems
KW - Medical applications
KW - Optimal experiment design
KW - Optimization problems
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U2 - 10.3182/20120711-3-BE-2027.00413
DO - 10.3182/20120711-3-BE-2027.00413
M3 - Conference contribution
AN - SCOPUS:84867060679
SN - 9783902823069
T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)
SP - 1311
EP - 1316
BT - SYSID 2012 - 16th IFAC Symposium on System Identification, Final Program
PB - IFAC Secretariat
T2 - Universite Libre de Bruxelles
Y2 - 11 July 2012 through 13 July 2012
ER -