Biomedical systems involve complex interactions between diverse components. Problem solving in such systems requires insight, i.e. the capability to make non-obvious connections. In this paper, we present a game-based problem solving environment, where users can explore biological interactions with navigation on atomic to macroscopic scales, role-play, and networked collaboration. The study investigates the system architecture of the biological game, bio-morphing characters, and bio-interactions with biosensing and biodynamics. The prototype has been implemented on PC and tested in a pre-school environment where users have little knowledge in biology. The experiment shows that the game greatly inspired users both in concept learning and entertainment.