Toward effective probiotics for autism and other neurodevelopmental disorders

Jack A. Gilbert; Rosa Krajmalnik-Brown; Dorota L. Porazinska; Sophie J. Weiss; Rob Knight

doi:10.1016/j.cell.2013.11.035

Toward effective probiotics for autism and other neurodevelopmental disorders

Jack A. Gilbert, Rosa Krajmalnik-Brown, Dorota L. Porazinska, Sophie J. Weiss, Rob Knight

Research output: Contribution to journal › Short survey › peer-review

74 Scopus citations

Abstract

Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

Original language	English (US)
Pages (from-to)	1446-1448
Number of pages	3
Journal	Cell
Volume	155
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2013.11.035
State	Published - Dec 19 2013

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.cell.2013.11.035

Cite this

@article{cb4bb45cca1c410b8d7766a6ab0ae755,

title = "Toward effective probiotics for autism and other neurodevelopmental disorders",

abstract = "Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.",

author = "Gilbert, {Jack A.} and Rosa Krajmalnik-Brown and Porazinska, {Dorota L.} and Weiss, {Sophie J.} and Rob Knight",

note = "Funding Information: R.K.B. is supported by the Autism Research Institute (ARI) and Bhare Autism Foundation, and R.K is supported by the Howard Hughes Medical Institute.",

year = "2013",

month = dec,

day = "19",

doi = "10.1016/j.cell.2013.11.035",

language = "English (US)",

volume = "155",

pages = "1446--1448",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "7",

}

TY - JOUR

T1 - Toward effective probiotics for autism and other neurodevelopmental disorders

AU - Gilbert, Jack A.

AU - Krajmalnik-Brown, Rosa

AU - Porazinska, Dorota L.

AU - Weiss, Sophie J.

AU - Knight, Rob

N1 - Funding Information: R.K.B. is supported by the Autism Research Institute (ARI) and Bhare Autism Foundation, and R.K is supported by the Howard Hughes Medical Institute.

PY - 2013/12/19

Y1 - 2013/12/19

N2 - Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

AB - Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

UR - http://www.scopus.com/inward/record.url?scp=84894588779&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894588779&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2013.11.035

DO - 10.1016/j.cell.2013.11.035

M3 - Short survey

C2 - 24360269

AN - SCOPUS:84894588779

SN - 0092-8674

VL - 155

SP - 1446

EP - 1448

JO - Cell

JF - Cell

IS - 7

ER -

Toward effective probiotics for autism and other neurodevelopmental disorders

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this