Toward a realistic model of mutations affecting fitness

Peter D. Keightley; Michael Lynch

doi:10.1111/j.0014-3820.2003.tb01561.x

Toward a realistic model of mutations affecting fitness

Peter D. Keightley, Michael Lynch

Research output: Contribution to journal › Short survey › peer-review

111 Scopus citations

Abstract

Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

Original language	English (US)
Pages (from-to)	683-685
Number of pages	3
Journal	Evolution
Volume	57
Issue number	3
DOIs	https://doi.org/10.1111/j.0014-3820.2003.tb01561.x
State	Published - Mar 1 2003
Externally published	Yes

Keywords

Arabidopsis
Mutation
Mutation accumulation
Mutational effects distribution
Statistical inference

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
General Agricultural and Biological Sciences

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10.1111/j.0014-3820.2003.tb01561.x

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title = "Toward a realistic model of mutations affecting fitness",

abstract = "Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.",

keywords = "Arabidopsis, Mutation, Mutation accumulation, Mutational effects distribution, Statistical inference",

author = "Keightley, {Peter D.} and Michael Lynch",

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doi = "10.1111/j.0014-3820.2003.tb01561.x",

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T1 - Toward a realistic model of mutations affecting fitness

AU - Keightley, Peter D.

AU - Lynch, Michael

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Y1 - 2003/3/1

N2 - Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

AB - Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.

KW - Arabidopsis

KW - Mutation

KW - Mutation accumulation

KW - Mutational effects distribution

KW - Statistical inference

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U2 - 10.1111/j.0014-3820.2003.tb01561.x

DO - 10.1111/j.0014-3820.2003.tb01561.x

M3 - Short survey

C2 - 12703958

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VL - 57

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EP - 685

JO - Evolution

JF - Evolution

IS - 3

ER -

Toward a realistic model of mutations affecting fitness

Abstract

Keywords

ASJC Scopus subject areas

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