Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans

Shaneda Warren Andersen, Xiao Ou Shu, Qiuyin Cai, Nikhil K. Khankari, Mark D. Steinwande, Peter Jurutka, William J. Blot, Wei Zheng

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Previous studies rarely evaluated the associations between Vitamin D-binding protein and free Vitamin D with colorectal cancer risk. We assessed these biomarkers and total 25- hydroxyVitamin D in relation to colorectal cancer risk in a sample of African Americans. Methods: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident colorectal cancer. Controls (N = 440) were selected through incidence density sampling and matched to cases on age, sex, and race. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between biomarker levels and colorectal cancer risk. Results: Vitamin D was inversely associated with colorectal cancer risk where the OR per-SD increase in total and free 25- hydroxyVitamin D were 0.82 (95% CI, 0.66-1.02) and 0.82 (95% CI, 0.66-1.01), respectively. Associations were most apparent among cases diagnosed <3 years after blood draw: ORs for the highest tertile versus the lowest were 0.69 (95% CI, 0.21-0.93) for total 25-hydroxyVitamin D and 0.71 (95% CI, 0.53-0.97) for free 25-hydroxyVitamin D. Inverse associations were seen in strata defined by sex, BMI, and anatomic site, although not all findings were statistically significant. Vitamin D-binding protein was not associated with colorectal cancer risk. Conclusions: Our findings suggest that total and free 25-hydroxyVitamin D may be inversely associated with colorectal cancer risk among African Americans. Impact: These findings highlight a potential role for Vitamin D in colorectal cancer prevention in African Americans.

Original languageEnglish (US)
Pages (from-to)1242-1247
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Vitamin D-Binding Protein
Vitamin D
African Americans
Colorectal Neoplasms
Prospective Studies
Confidence Intervals
Odds Ratio
Biomarkers
Cohort Studies
Logistic Models
25-hydroxyvitamin D

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans. / Andersen, Shaneda Warren; Shu, Xiao Ou; Cai, Qiuyin; Khankari, Nikhil K.; Steinwande, Mark D.; Jurutka, Peter; Blot, William J.; Zheng, Wei.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 26, No. 8, 01.08.2017, p. 1242-1247.

Research output: Contribution to journalArticle

Andersen, Shaneda Warren ; Shu, Xiao Ou ; Cai, Qiuyin ; Khankari, Nikhil K. ; Steinwande, Mark D. ; Jurutka, Peter ; Blot, William J. ; Zheng, Wei. / Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans. In: Cancer Epidemiology Biomarkers and Prevention. 2017 ; Vol. 26, No. 8. pp. 1242-1247.
@article{134ee9cd0e0e4b0083c6e1f5060e79dc,
title = "Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans",
abstract = "Background: Previous studies rarely evaluated the associations between Vitamin D-binding protein and free Vitamin D with colorectal cancer risk. We assessed these biomarkers and total 25- hydroxyVitamin D in relation to colorectal cancer risk in a sample of African Americans. Methods: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident colorectal cancer. Controls (N = 440) were selected through incidence density sampling and matched to cases on age, sex, and race. Conditional logistic regression was used to calculate odds ratios (OR) and 95{\%} confidence intervals (CI) for associations between biomarker levels and colorectal cancer risk. Results: Vitamin D was inversely associated with colorectal cancer risk where the OR per-SD increase in total and free 25- hydroxyVitamin D were 0.82 (95{\%} CI, 0.66-1.02) and 0.82 (95{\%} CI, 0.66-1.01), respectively. Associations were most apparent among cases diagnosed <3 years after blood draw: ORs for the highest tertile versus the lowest were 0.69 (95{\%} CI, 0.21-0.93) for total 25-hydroxyVitamin D and 0.71 (95{\%} CI, 0.53-0.97) for free 25-hydroxyVitamin D. Inverse associations were seen in strata defined by sex, BMI, and anatomic site, although not all findings were statistically significant. Vitamin D-binding protein was not associated with colorectal cancer risk. Conclusions: Our findings suggest that total and free 25-hydroxyVitamin D may be inversely associated with colorectal cancer risk among African Americans. Impact: These findings highlight a potential role for Vitamin D in colorectal cancer prevention in African Americans.",
author = "Andersen, {Shaneda Warren} and Shu, {Xiao Ou} and Qiuyin Cai and Khankari, {Nikhil K.} and Steinwande, {Mark D.} and Peter Jurutka and Blot, {William J.} and Wei Zheng",
year = "2017",
month = "8",
day = "1",
doi = "10.1158/1055-9965.EPI-17-0133",
language = "English (US)",
volume = "26",
pages = "1242--1247",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "8",

}

TY - JOUR

T1 - Total and free circulating Vitamin D and Vitamin D-binding protein in relation to colorectal cancer risk in a prospective study of African Americans

AU - Andersen, Shaneda Warren

AU - Shu, Xiao Ou

AU - Cai, Qiuyin

AU - Khankari, Nikhil K.

AU - Steinwande, Mark D.

AU - Jurutka, Peter

AU - Blot, William J.

AU - Zheng, Wei

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: Previous studies rarely evaluated the associations between Vitamin D-binding protein and free Vitamin D with colorectal cancer risk. We assessed these biomarkers and total 25- hydroxyVitamin D in relation to colorectal cancer risk in a sample of African Americans. Methods: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident colorectal cancer. Controls (N = 440) were selected through incidence density sampling and matched to cases on age, sex, and race. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between biomarker levels and colorectal cancer risk. Results: Vitamin D was inversely associated with colorectal cancer risk where the OR per-SD increase in total and free 25- hydroxyVitamin D were 0.82 (95% CI, 0.66-1.02) and 0.82 (95% CI, 0.66-1.01), respectively. Associations were most apparent among cases diagnosed <3 years after blood draw: ORs for the highest tertile versus the lowest were 0.69 (95% CI, 0.21-0.93) for total 25-hydroxyVitamin D and 0.71 (95% CI, 0.53-0.97) for free 25-hydroxyVitamin D. Inverse associations were seen in strata defined by sex, BMI, and anatomic site, although not all findings were statistically significant. Vitamin D-binding protein was not associated with colorectal cancer risk. Conclusions: Our findings suggest that total and free 25-hydroxyVitamin D may be inversely associated with colorectal cancer risk among African Americans. Impact: These findings highlight a potential role for Vitamin D in colorectal cancer prevention in African Americans.

AB - Background: Previous studies rarely evaluated the associations between Vitamin D-binding protein and free Vitamin D with colorectal cancer risk. We assessed these biomarkers and total 25- hydroxyVitamin D in relation to colorectal cancer risk in a sample of African Americans. Methods: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident colorectal cancer. Controls (N = 440) were selected through incidence density sampling and matched to cases on age, sex, and race. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between biomarker levels and colorectal cancer risk. Results: Vitamin D was inversely associated with colorectal cancer risk where the OR per-SD increase in total and free 25- hydroxyVitamin D were 0.82 (95% CI, 0.66-1.02) and 0.82 (95% CI, 0.66-1.01), respectively. Associations were most apparent among cases diagnosed <3 years after blood draw: ORs for the highest tertile versus the lowest were 0.69 (95% CI, 0.21-0.93) for total 25-hydroxyVitamin D and 0.71 (95% CI, 0.53-0.97) for free 25-hydroxyVitamin D. Inverse associations were seen in strata defined by sex, BMI, and anatomic site, although not all findings were statistically significant. Vitamin D-binding protein was not associated with colorectal cancer risk. Conclusions: Our findings suggest that total and free 25-hydroxyVitamin D may be inversely associated with colorectal cancer risk among African Americans. Impact: These findings highlight a potential role for Vitamin D in colorectal cancer prevention in African Americans.

UR - http://www.scopus.com/inward/record.url?scp=85026817701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026817701&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-17-0133

DO - 10.1158/1055-9965.EPI-17-0133

M3 - Article

C2 - 28483970

AN - SCOPUS:85026817701

VL - 26

SP - 1242

EP - 1247

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 8

ER -