To treat or not to treat

The case of tuberculosis

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Incomplete treatment of patients with infectious tuberculosis (TB) may not only lead to relapse but also to the development of antibiotic resistant TB - one of the most serious health problems facing society today. In this article, we formulate one-strain and two-strain TB models to determine possible mechanisms that may allow for the survival and spread of naturally resistant strains of TB as well as antibiotic-generated resistant strains of TB. Analysis of our models shows that non-antibiotic co-existence is possible but rare for naturally resistant strains while co-existence is almost the rule for strains that result from the lack of compliance with antibiotic treatment by TB infected individuals.

Original languageEnglish (US)
Pages (from-to)629-656
Number of pages28
JournalJournal of Mathematical Biology
Volume35
Issue number6
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Tuberculosis
Antibiotics
tuberculosis
antibiotics
Medical problems
Anti-Bacterial Agents
Coexistence
relapse
Compliance
compliance
Health
Recurrence
Survival
Therapeutics
Model

Keywords

  • Antibiotic resistance
  • Co-existence
  • Dynamical systems
  • Epidemiology
  • Tuberculosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Mathematics (miscellaneous)

Cite this

To treat or not to treat : The case of tuberculosis. / Castillo-Chavez, Carlos; Feng, Zhilan.

In: Journal of Mathematical Biology, Vol. 35, No. 6, 06.1997, p. 629-656.

Research output: Contribution to journalArticle

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