Abstract
Incomplete treatment of patients with infectious tuberculosis (TB) may not only lead to relapse but also to the development of antibiotic resistant TB - one of the most serious health problems facing society today. In this article, we formulate one-strain and two-strain TB models to determine possible mechanisms that may allow for the survival and spread of naturally resistant strains of TB as well as antibiotic-generated resistant strains of TB. Analysis of our models shows that non-antibiotic co-existence is possible but rare for naturally resistant strains while co-existence is almost the rule for strains that result from the lack of compliance with antibiotic treatment by TB infected individuals.
Original language | English (US) |
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Pages (from-to) | 629-656 |
Number of pages | 28 |
Journal | Journal Of Mathematical Biology |
Volume | 35 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1997 |
Externally published | Yes |
Keywords
- Antibiotic resistance
- Co-existence
- Dynamical systems
- Epidemiology
- Tuberculosis
ASJC Scopus subject areas
- Modeling and Simulation
- Agricultural and Biological Sciences (miscellaneous)
- Applied Mathematics