Thymus-derived lymphocyte differentiation and lymphocytic leukemias. I. Evidence for the existence of functionally different subpopulations of thymus-derived cells in leukemic AKR mice

Anna D. Barker, Samuel D. Waksal

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effects of transplanting thymic (LTC), splenic (LSC), and lymph node (LLNC) lymphocytes derived from overtly leukemic AKR mice into preleukemic syngeneic animals were studied. Each of these thymus-derived (T cell) populations produced a different and distinct pathology in recipient mice. Animals receiving LTC exhibited thymoma and enlargement of peripheral lymphoid tissues. Gross organomegaly was also noted in mice given LSC, but thymic atrophy was uniformly observed. The thymus appeared normal in mice receiving LLNC, but marked enlargement of peripheral lymphoid tissues again were observed. The differences noted in disease pathologies correlated with the "homing" patterns of the subpopulations investigated. These findings suggest that subpopulations of T cells exist in mice with a thymus-derived neoplastic disorder.

Original languageEnglish (US)
Pages (from-to)140-149
Number of pages10
JournalCellular Immunology
Volume12
Issue number1
DOIs
StatePublished - Apr 1974

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Thymus-derived lymphocyte differentiation and lymphocytic leukemias. I. Evidence for the existence of functionally different subpopulations of thymus-derived cells in leukemic AKR mice'. Together they form a unique fingerprint.

  • Cite this