Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK

Ya ming Xu, Jeffrey A. Smith, Deborah A. Lannigan, Sidney M. Hecht

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

A survey of plant extracts for the presence of p90 ribosomal S6 kinase (RSK) inhibitors resulted in the isolation of three acetylated flavonol glycosides. Kaempferol 3-O-(2″,4″-O-diacetyl-α-l-rhamnopyranoside) (1), kaempferol 3-O-(3″,4″-O-diacetyl-α-l-rhamnopyranoside) (2), and kaempferol-3-O-(4″-O-acetyl-α-l-rhamnopyranoside) (3) were isolated from Forsteronia refracta as the first RSK inhibitors. Of these, compound 2 was found to be the best inhibitor with an IC50 value of 89 nM.

Original languageEnglish (US)
Pages (from-to)3974-3977
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume14
Issue number11
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

Keywords

  • Acetylated kaempferol-3-O-α-l-rhamnopyranosides
  • Apocynaceae
  • Forsteronia refracta
  • RSK inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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