Thermoelectric enzyme sensor for measuring blood glucose

Michael J. Muehlbauer, Eric J. Guilbeau, Bruce C. Towe, Tedd A. Brandon

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

A new calorimetric sensor has been developed which employs a thin-film thermopile in association with an immobilized enzyme. The thermopile detects the minute temperature rise that occurs when a specific chemical substrate is catalyzed by the enzyme. A prototype sensor is described which generates an equivalent proportional voltage response to glucose concentrations present in either buffer solution or blood. These sensors have remained useful for up to 18 days when operated intermittently for measuring glucose in buffer solutions, or for up to 4 days when operated continuously. When implanted inside cardiovascular shunts on anesthetized dogs, the sensors responded appropriately to changes in the blood glucose concentration.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBiosensors and Bioelectronics
Volume5
Issue number1
DOIs
StatePublished - 1990

Keywords

  • blood glucose
  • calorimetric
  • catalase
  • catheter
  • enzyme
  • glucose oxidase
  • implantation
  • stability
  • thermoelectric
  • thermopile

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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  • Cite this

    Muehlbauer, M. J., Guilbeau, E. J., Towe, B. C., & Brandon, T. A. (1990). Thermoelectric enzyme sensor for measuring blood glucose. Biosensors and Bioelectronics, 5(1), 1-12. https://doi.org/10.1016/0956-5663(90)80022-6