Thermo-responsive core-shell composite nanoparticles synthesized via one-step pickering emulsion polymerization for controlled drug delivery

Sriya Sanyal, Huang Chiao Huang, Kaushal Rege, Lenore Dai

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.

Original languageEnglish (US)
JournalJournal of Nanomedicine and Nanotechnology
Volume2
Issue number7
DOIs
StatePublished - Dec 2011

Keywords

  • Composite nanoparticles
  • Cytotoxicity
  • Drug release
  • Pickering emulsion polymerization
  • Temperature sensitivity

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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