Thermo-responsive core-shell composite nanoparticles synthesized via one-step pickering emulsion polymerization for controlled drug delivery

Sriya Sanyal, Huang Chiao Huang, Kaushal Rege, Lenore Dai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.

Original languageEnglish (US)
JournalJournal of Nanomedicine and Nanotechnology
Volume2
Issue number7
DOIs
StatePublished - Dec 2011

Fingerprint

Controlled drug delivery
Emulsion polymerization
Emulsions
Polymerization
Nanoparticles
Composite materials
Pharmaceutical Preparations
Prostatic Neoplasms
Cells
tanespimycin
Silicon Dioxide
Temperature
Silica
Polystyrenes
Drug delivery
Antineoplastic Agents
Monomers
Drug Liberation
Neoplasms

Keywords

  • Composite nanoparticles
  • Cytotoxicity
  • Drug release
  • Pickering emulsion polymerization
  • Temperature sensitivity

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Pharmaceutical Science

Cite this

@article{dc774f00774442b2af3e518c92916636,
title = "Thermo-responsive core-shell composite nanoparticles synthesized via one-step pickering emulsion polymerization for controlled drug delivery",
abstract = "Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.",
keywords = "Composite nanoparticles, Cytotoxicity, Drug release, Pickering emulsion polymerization, Temperature sensitivity",
author = "Sriya Sanyal and Huang, {Huang Chiao} and Kaushal Rege and Lenore Dai",
year = "2011",
month = "12",
doi = "10.4172/2157-7439.1000126",
language = "English (US)",
volume = "2",
journal = "Journal of Nanomedicine and Nanotechnology",
issn = "2157-7439",
publisher = "OMICS Publishing Group",
number = "7",

}

TY - JOUR

T1 - Thermo-responsive core-shell composite nanoparticles synthesized via one-step pickering emulsion polymerization for controlled drug delivery

AU - Sanyal, Sriya

AU - Huang, Huang Chiao

AU - Rege, Kaushal

AU - Dai, Lenore

PY - 2011/12

Y1 - 2011/12

N2 - Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.

AB - Purpose: The focus of this work is to develop a unique drug delivery vehicle which can be taken up by cancer cells and can release the loaded drug. Methods: Core-shell composite nanoparticles have been prepared by one-step Pickering emulsion polymerization with a nonionic initiator, using silica as the sole stabilizer. More importantly, the Pickering emulsion polymerization is applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. Results: The composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3 and PC3-PSMA) cells. An anticancer agent 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) has been loaded into the polymeric cores during formation of the nanoparticles and drug release has been successfully observed at elevated temperatures. The ability of the various nanoparticles for inducing death in human prostate cancer cells has been evaluated. Conclusion: The work has demonstrated the temperature sensitivity, controlled drug release properties of the synthesized core-shell nanoparticles, and their effectiveness for inducing death of human prostate cancer cells.

KW - Composite nanoparticles

KW - Cytotoxicity

KW - Drug release

KW - Pickering emulsion polymerization

KW - Temperature sensitivity

UR - http://www.scopus.com/inward/record.url?scp=84868362805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868362805&partnerID=8YFLogxK

U2 - 10.4172/2157-7439.1000126

DO - 10.4172/2157-7439.1000126

M3 - Article

VL - 2

JO - Journal of Nanomedicine and Nanotechnology

JF - Journal of Nanomedicine and Nanotechnology

SN - 2157-7439

IS - 7

ER -