TY - JOUR
T1 - Therapeutic vaccination against chronic viral infection
T2 - The importance of cooperation between CD4+ and CD8+ T cells
AU - Zajac, Allan J.
AU - Murali-Krishna, Kaja
AU - Blattman, Joseph N.
AU - Ahmed, Rafi
N1 - Funding Information:
Wew ish IO thank D Quinn and hl Jabbar for helpful advice and discussion and gratefully acknowledge the supporto f Narional Inscicutes for Health grants AI 30048 and NS 21496 (to RA). AJZ is a recipient of fellowship DRG-1421 from rhe Damon Runyon-Walter Winchell foundation.
PY - 1998/8
Y1 - 1998/8
N2 - The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.
AB - The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.
UR - http://www.scopus.com/inward/record.url?scp=0032146748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032146748&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(98)80119-2
DO - 10.1016/S0952-7915(98)80119-2
M3 - Article
C2 - 9722921
AN - SCOPUS:0032146748
SN - 0952-7915
VL - 10
SP - 444
EP - 449
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -