Therapeutic vaccination against chronic viral infection

The importance of cooperation between CD4+ and CD8+ T cells

Allan J. Zajac, Kaja Murali-Krishna, Joseph Blattman, Rafi Ahmed

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

Original languageEnglish (US)
Pages (from-to)444-449
Number of pages6
JournalCurrent Opinion in Immunology
Volume10
Issue number4
DOIs
StatePublished - Aug 1998
Externally publishedYes

Fingerprint

Virus Diseases
Vaccination
T-Lymphocytes
Antiviral Agents
Therapeutics
Infection
Viruses

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Therapeutic vaccination against chronic viral infection : The importance of cooperation between CD4+ and CD8+ T cells. / Zajac, Allan J.; Murali-Krishna, Kaja; Blattman, Joseph; Ahmed, Rafi.

In: Current Opinion in Immunology, Vol. 10, No. 4, 08.1998, p. 444-449.

Research output: Contribution to journalArticle

@article{a8dab79b9d8b4507becfa1968332962c,
title = "Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cells",
abstract = "The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.",
author = "Zajac, {Allan J.} and Kaja Murali-Krishna and Joseph Blattman and Rafi Ahmed",
year = "1998",
month = "8",
doi = "10.1016/S0952-7915(98)80119-2",
language = "English (US)",
volume = "10",
pages = "444--449",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Therapeutic vaccination against chronic viral infection

T2 - The importance of cooperation between CD4+ and CD8+ T cells

AU - Zajac, Allan J.

AU - Murali-Krishna, Kaja

AU - Blattman, Joseph

AU - Ahmed, Rafi

PY - 1998/8

Y1 - 1998/8

N2 - The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

AB - The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

UR - http://www.scopus.com/inward/record.url?scp=0032146748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032146748&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(98)80119-2

DO - 10.1016/S0952-7915(98)80119-2

M3 - Article

VL - 10

SP - 444

EP - 449

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 4

ER -