Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4+ and CD8+ T cells

Allan J. Zajac, Kaja Murali-Krishna, Joseph N. Blattman, Rafi Ahmed

Research output: Contribution to journalArticle

102 Scopus citations


The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

Original languageEnglish (US)
Pages (from-to)444-449
Number of pages6
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1998


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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