Therapeutic Potential of Peroxisome Proliferator-Activated Receptors in Chronic Inflammation and Colorectal Cancer

Dingzhi Wang, Raymond DuBois

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Peroxisome proliferatoreactivated receptors (PPARs) are members of the nuclear hormone receptor superfamily and have been implicated in a variety of physiologic and pathologic processes, such as nutrient metabolism, energy homeostasis, inflammation, and cancer. This article highlights breakthroughs in our understanding of the potential roles of PPARs in inflammatory bowel disease and colorectal cancer. PPARs might hold the key to some of the questions that are pertinent to the pathophysiology of inflammatory diseases and colorectal cancer and could possibly serve as drug targets for new antiinflammatory therapeutic and anticancer agents.

Original languageEnglish (US)
Pages (from-to)697-707
Number of pages11
JournalGastroenterology Clinics of North America
Volume39
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • Chronic inflammation
  • Colorectal cancer
  • Inflammatory bowel disease
  • Peroxisome proliferator-activated receptor

ASJC Scopus subject areas

  • Gastroenterology

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