Therapeutic neovascularization promoted by injectable hydrogels

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors.

Original languageEnglish (US)
Pages (from-to)389-400
Number of pages12
JournalBioactive Materials
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2018

Fingerprint

Hydrogels
Repair
Tissue
Angiogenesis Inducing Agents
Injections
Stem Cells
Intercellular Signaling Peptides and Proteins
Blood vessels
Biocompatible Materials
Therapeutics
Stem cells
Biomaterials
Wound Healing
Blood Vessels
Regeneration
Molecules
Testing

Keywords

  • Angiogenic factors
  • Cell-therapy
  • Injectable hydrogels
  • Neovascularization
  • Tissue regeneration

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biotechnology
  • Biomaterials

Cite this

Therapeutic neovascularization promoted by injectable hydrogels. / Pal, Amrita; Vernon, Brent; Nikkhah, Mehdi.

In: Bioactive Materials, Vol. 3, No. 4, 01.12.2018, p. 389-400.

Research output: Contribution to journalReview article

@article{4f4cb4e96a47495594a6c08ef1bbda87,
title = "Therapeutic neovascularization promoted by injectable hydrogels",
abstract = "The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors.",
keywords = "Angiogenic factors, Cell-therapy, Injectable hydrogels, Neovascularization, Tissue regeneration",
author = "Amrita Pal and Brent Vernon and Mehdi Nikkhah",
year = "2018",
month = "12",
day = "1",
doi = "10.1016/j.bioactmat.2018.05.002",
language = "English (US)",
volume = "3",
pages = "389--400",
journal = "Bioactive Materials",
issn = "2452-199X",
publisher = "KeAi Communications Co",
number = "4",

}

TY - JOUR

T1 - Therapeutic neovascularization promoted by injectable hydrogels

AU - Pal, Amrita

AU - Vernon, Brent

AU - Nikkhah, Mehdi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors.

AB - The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors, stem cells or expansion of pre-existing cells. For efficient neovascularization, controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site. In this regard, injectable hydrogels, made of natural, synthetic or hybrid biomaterials, have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair, regeneration and neovascularization. This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors, and their applications in ischemic tissue repair and wound healing. We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization. We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors.

KW - Angiogenic factors

KW - Cell-therapy

KW - Injectable hydrogels

KW - Neovascularization

KW - Tissue regeneration

UR - http://www.scopus.com/inward/record.url?scp=85051503731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051503731&partnerID=8YFLogxK

U2 - 10.1016/j.bioactmat.2018.05.002

DO - 10.1016/j.bioactmat.2018.05.002

M3 - Review article

AN - SCOPUS:85051503731

VL - 3

SP - 389

EP - 400

JO - Bioactive Materials

JF - Bioactive Materials

SN - 2452-199X

IS - 4

ER -