Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds

M. Raible; M. Evstigneev; F. W. Bartels; R. Eckel; M. Nguyen-Duong; R. Merkel; R. Ros; D. Anselmetti; P. Reimann

doi:10.1529/biophysj.105.077099

Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds

M. Raible, M. Evstigneev, F. W. Bartels, R. Eckel, M. Nguyen-Duong, R. Merkel, R. Ros, D. Anselmetti, P. Reimann

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.

Original language	English (US)
Pages (from-to)	3851-3864
Number of pages	14
Journal	Biophysical journal
Volume	90
Issue number	11
DOIs	https://doi.org/10.1529/biophysj.105.077099
State	Published - Jun 2006
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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title = "Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds",

abstract = "We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.",

author = "M. Raible and M. Evstigneev and Bartels, {F. W.} and R. Eckel and M. Nguyen-Duong and R. Merkel and R. Ros and D. Anselmetti and P. Reimann",

note = "Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft under grant No. SFB 613, grant No. ME 1458/3, grant No. RE 1344/3-1, the Alexander von Humboldt-Stiftung, and the European Science Foundation program STOCHDYN.",

year = "2006",

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doi = "10.1529/biophysj.105.077099",

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T1 - Theoretical analysis of single-molecule force spectroscopy experiments

T2 - Heterogeneity of chemical bonds

AU - Raible, M.

AU - Evstigneev, M.

AU - Bartels, F. W.

AU - Eckel, R.

AU - Nguyen-Duong, M.

AU - Merkel, R.

AU - Ros, R.

AU - Anselmetti, D.

AU - Reimann, P.

N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft under grant No. SFB 613, grant No. ME 1458/3, grant No. RE 1344/3-1, the Alexander von Humboldt-Stiftung, and the European Science Foundation program STOCHDYN.

PY - 2006/6

Y1 - 2006/6

N2 - We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.

AB - We show that the standard theoretical framework in single-molecule force spectroscopy has to be extended to consistently describe the experimental findings. The basic amendment is to take into account heterogeneity of the chemical bonds via random variations of the force-dependent dissociation rates. This results in a very good agreement between theory and rupture data from several different experiments.

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JF - Biophysical journal

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ER -

Theoretical analysis of single-molecule force spectroscopy experiments: Heterogeneity of chemical bonds

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