The Weak Shall Inherit

Bacteriocin-Mediated Interactions in Bacterial Populations

Hadeel Majeed, Adam Lampert, Lusine Ghazaryan, Osnat Gillor

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background:Evolutionary arms race plays a major role in shaping biological diversity. In microbial systems, competition often involves chemical warfare and the production of bacteriocins, narrow-spectrum toxins aimed at killing closely related strains by forming pores in their target's membrane or by degrading the target's RNA or DNA. Although many empirical and theoretical studies describe competitive exclusion of bacteriocin-sensitive strains by producers of bacteriocins, the dynamics among producers are largely unknown.Methodology/Principal findings:We used a reporter-gene assay to show that the bacterial response to bacteriocins' treatment mirrors the inflicted damage Potent bacteriocins are lethal to competing strains, but at sublethal doses can serve as strong inducing agents, enhancing their antagonists' bacteriocin production. In contrast, weaker bacteriocins are less toxic to their competitors and trigger mild bacteriocin expression. We used empirical and numerical models to explore the role of cross-induction in the arms race between bacteriocin-producing strains. We found that in well-mixed, unstructured environments where interactions are global, producers of weak bacteriocins are selectively advantageous and outcompete producers of potent bacteriocins. However, in spatially structured environments, where interactions are local, each producer occupies its own territory, and competition takes place only in "no man's lands" between territories, resulting in much slower dynamics.Conclusion/Significance:The models we present imply that producers of potent bacteriocins that trigger a strong response in neighboring bacteriocinogenic strains are doomed, while producers of weak bacteriocins that trigger a mild response in bacteriocinogenic strains flourish. This counter-intuitive outcome might explain the preponderance of weak bacteriocin producers in nature. However, the described scenario is prolonged in spatially structured environments thus promoting coexistence, allowing migration and evolution, and maintaining bacterial diversity.

Original languageEnglish (US)
Article numbere63837
JournalPLoS One
Volume8
Issue number5
DOIs
StatePublished - May 21 2013
Externally publishedYes

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Bacteriocins
bacteriocins
Population
Chemical Warfare
Chemical warfare
competitive exclusion
Poisons
Biodiversity
lethal genes
Reporter Genes
reporter genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The Weak Shall Inherit : Bacteriocin-Mediated Interactions in Bacterial Populations. / Majeed, Hadeel; Lampert, Adam; Ghazaryan, Lusine; Gillor, Osnat.

In: PLoS One, Vol. 8, No. 5, e63837, 21.05.2013.

Research output: Contribution to journalArticle

Majeed, Hadeel ; Lampert, Adam ; Ghazaryan, Lusine ; Gillor, Osnat. / The Weak Shall Inherit : Bacteriocin-Mediated Interactions in Bacterial Populations. In: PLoS One. 2013 ; Vol. 8, No. 5.
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