TY - GEN
T1 - The value of inflammatory signals in adaptive immune responses
AU - Banerjee, Soumya
AU - Levin, Drew
AU - Moses, Melanie
AU - Koster, Frederick
AU - Forrest, Stephanie
PY - 2011
Y1 - 2011
N2 - Cells of the immune system search among billions of healthy cells to find and neutralize a small number of infected cells before pathogens replicate to sufficient numbers to cause disease or death. The immune system uses information signals to accomplish this search quickly. Ordinary differential equations and spatially explicit agent-based models are used to quantify how capillary inflammation decreases the time it takes for cytotoxic T lymphocytes to find and kill infected cells. We find that the inflammation signal localized in a small region of infected tissue dramatically reduces search times, suggesting that these signals play an important role in the immune response, especially in larger animals.
AB - Cells of the immune system search among billions of healthy cells to find and neutralize a small number of infected cells before pathogens replicate to sufficient numbers to cause disease or death. The immune system uses information signals to accomplish this search quickly. Ordinary differential equations and spatially explicit agent-based models are used to quantify how capillary inflammation decreases the time it takes for cytotoxic T lymphocytes to find and kill infected cells. We find that the inflammation signal localized in a small region of infected tissue dramatically reduces search times, suggesting that these signals play an important role in the immune response, especially in larger animals.
UR - http://www.scopus.com/inward/record.url?scp=79960373737&partnerID=8YFLogxK
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U2 - 10.1007/978-3-642-22371-6_1
DO - 10.1007/978-3-642-22371-6_1
M3 - Conference contribution
AN - SCOPUS:79960373737
SN - 9783642223709
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 1
EP - 14
BT - Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
T2 - 10th International Conference on Artificial Immune Systems, ICARIS 2011
Y2 - 18 July 2011 through 21 July 2011
ER -