The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

Evan P. Kingsley, Krzysztof M. Kozak, Susanne Pfeifer, Dou Shuan Yang, Hopi E. Hoekstra

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mouse, Peromyscus maniculatus, which occupies two main habitat types: prairie and forest. Using historical collections, we find that forest-dwelling mice have longer tails than those from nonforested habitat, even when we account for individual and population relatedness. Using genome-wide SNP data, we show that mice from forested habitats in the eastern and western parts of their range form separate clades, suggesting that increased tail length evolved independently. We find that forest mice in the east and west have both more and longer caudal vertebrae, but not trunk vertebrae, than nearby prairie forms. By intercrossing prairie and forest mice, we show that the number and length of caudal vertebrae are not correlated in this recombinant population, indicating that variation in these traits is controlled by separate genetic loci. Together, these results demonstrate convergent evolution of the long-tailed forest phenotype through two distinct genetic mechanisms, affecting number and length of vertebrae, and suggest that these morphological changes—either independently or together—are adaptive.

Original languageEnglish (US)
Pages (from-to)261-273
Number of pages13
JournalEvolution
Volume71
Issue number2
DOIs
StatePublished - Feb 1 2017

Fingerprint

Peromyscus
deer
Tail
vertebrae
tail
Spine
prairies
prairie
Ecosystem
mice
habitats
convergent evolution
tool use
Peromyscus maniculatus
Genetic Loci
local adaptation
evolutionary biology
habitat
relatedness
habitat type

Keywords

  • Caudal vertebrae
  • convergence
  • local adaptation
  • parallel evolution
  • Peromyscus maniculatus
  • skeletal evolution

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice. / Kingsley, Evan P.; Kozak, Krzysztof M.; Pfeifer, Susanne; Yang, Dou Shuan; Hoekstra, Hopi E.

In: Evolution, Vol. 71, No. 2, 01.02.2017, p. 261-273.

Research output: Contribution to journalArticle

Kingsley, Evan P. ; Kozak, Krzysztof M. ; Pfeifer, Susanne ; Yang, Dou Shuan ; Hoekstra, Hopi E. / The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice. In: Evolution. 2017 ; Vol. 71, No. 2. pp. 261-273.
@article{450b12f54aaa434a9edd45a852bcb02b,
title = "The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice",
abstract = "Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mouse, Peromyscus maniculatus, which occupies two main habitat types: prairie and forest. Using historical collections, we find that forest-dwelling mice have longer tails than those from nonforested habitat, even when we account for individual and population relatedness. Using genome-wide SNP data, we show that mice from forested habitats in the eastern and western parts of their range form separate clades, suggesting that increased tail length evolved independently. We find that forest mice in the east and west have both more and longer caudal vertebrae, but not trunk vertebrae, than nearby prairie forms. By intercrossing prairie and forest mice, we show that the number and length of caudal vertebrae are not correlated in this recombinant population, indicating that variation in these traits is controlled by separate genetic loci. Together, these results demonstrate convergent evolution of the long-tailed forest phenotype through two distinct genetic mechanisms, affecting number and length of vertebrae, and suggest that these morphological changes—either independently or together—are adaptive.",
keywords = "Caudal vertebrae, convergence, local adaptation, parallel evolution, Peromyscus maniculatus, skeletal evolution",
author = "Kingsley, {Evan P.} and Kozak, {Krzysztof M.} and Susanne Pfeifer and Yang, {Dou Shuan} and Hoekstra, {Hopi E.}",
year = "2017",
month = "2",
day = "1",
doi = "10.1111/evo.13150",
language = "English (US)",
volume = "71",
pages = "261--273",
journal = "Evolution; international journal of organic evolution",
issn = "0014-3820",
publisher = "Society for the Study of Evolution",
number = "2",

}

TY - JOUR

T1 - The ultimate and proximate mechanisms driving the evolution of long tails in forest deer mice

AU - Kingsley, Evan P.

AU - Kozak, Krzysztof M.

AU - Pfeifer, Susanne

AU - Yang, Dou Shuan

AU - Hoekstra, Hopi E.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mouse, Peromyscus maniculatus, which occupies two main habitat types: prairie and forest. Using historical collections, we find that forest-dwelling mice have longer tails than those from nonforested habitat, even when we account for individual and population relatedness. Using genome-wide SNP data, we show that mice from forested habitats in the eastern and western parts of their range form separate clades, suggesting that increased tail length evolved independently. We find that forest mice in the east and west have both more and longer caudal vertebrae, but not trunk vertebrae, than nearby prairie forms. By intercrossing prairie and forest mice, we show that the number and length of caudal vertebrae are not correlated in this recombinant population, indicating that variation in these traits is controlled by separate genetic loci. Together, these results demonstrate convergent evolution of the long-tailed forest phenotype through two distinct genetic mechanisms, affecting number and length of vertebrae, and suggest that these morphological changes—either independently or together—are adaptive.

AB - Understanding both the role of selection in driving phenotypic change and its underlying genetic basis remain major challenges in evolutionary biology. Here, we use modern tools to revisit a classic system of local adaptation in the North American deer mouse, Peromyscus maniculatus, which occupies two main habitat types: prairie and forest. Using historical collections, we find that forest-dwelling mice have longer tails than those from nonforested habitat, even when we account for individual and population relatedness. Using genome-wide SNP data, we show that mice from forested habitats in the eastern and western parts of their range form separate clades, suggesting that increased tail length evolved independently. We find that forest mice in the east and west have both more and longer caudal vertebrae, but not trunk vertebrae, than nearby prairie forms. By intercrossing prairie and forest mice, we show that the number and length of caudal vertebrae are not correlated in this recombinant population, indicating that variation in these traits is controlled by separate genetic loci. Together, these results demonstrate convergent evolution of the long-tailed forest phenotype through two distinct genetic mechanisms, affecting number and length of vertebrae, and suggest that these morphological changes—either independently or together—are adaptive.

KW - Caudal vertebrae

KW - convergence

KW - local adaptation

KW - parallel evolution

KW - Peromyscus maniculatus

KW - skeletal evolution

UR - http://www.scopus.com/inward/record.url?scp=85011887431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011887431&partnerID=8YFLogxK

U2 - 10.1111/evo.13150

DO - 10.1111/evo.13150

M3 - Article

C2 - 27958661

AN - SCOPUS:85011887431

VL - 71

SP - 261

EP - 273

JO - Evolution; international journal of organic evolution

JF - Evolution; international journal of organic evolution

SN - 0014-3820

IS - 2

ER -