The ubiquitin-proteasome system in Alzheimer's disease

Research output: Contribution to journalArticle

161 Scopus citations

Abstract

Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system (UPS). Indeed, there is clear genetic and biochemical evidence of an involvement of the ubiquitin proteasome system in AD. This review summarizes the data supporting an involvement of the UPS in the pathogenesis of AD, focusing on the data showing the relationship between Aβ and tau, the two hallmark lesions of AD, and the UPS.

Original languageEnglish (US)
Pages (from-to)363-373
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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