The ubiquitin-proteasome system in Alzheimer's disease

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD).Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system (UPS). Indeed, there is clear genetic and biochemical evidence of an involvement of the ubiquitin proteasome system in AD. This review summarizes the data supporting an involvement of the UPS in the pathogenesis of AD, focusing on the data showing the relationship between Aβ and tau, the two hallmark lesions of AD, and the UPS.

Original languageEnglish (US)
Pages (from-to)363-373
Number of pages11
JournalJournal of Cellular and Molecular Medicine
Volume12
Issue number2
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Proteasome Endopeptidase Complex
Ubiquitin
Alzheimer Disease
Neurodegenerative diseases
Neurodegenerative Diseases
Molecular Biology
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

The ubiquitin-proteasome system in Alzheimer's disease. / Oddo, Salvatore.

In: Journal of Cellular and Molecular Medicine, Vol. 12, No. 2, 04.2008, p. 363-373.

Research output: Contribution to journalArticle

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