The tumor microenvironment in colorectal carcinogenesis

Vijay G. Peddareddigari, Dingzhi Wang, Raymond N. Dubois

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Colorectal cancer is the second leading cause of cancer-related mortality in the United States. Therapeutic developments in the past decade have extended life expectancy in patients with metastatic disease. However, metastatic colorectal cancers remain incurable. Numerous agents that were demonstrated to have significant antitumor activity in experimental models translated into disappointing results in extending patient survival. This has resulted in more attention being focused on the contribution of tumor microenvironment to the progression of a number of solid tumors including colorectal cancer. A more complete understanding of interactions between tumor epithelial cells and their stromal elements will enhance therapeutic options and improve clinical outcome. Here we will review the role of various stromal components in colorectal carcinogenesis and discuss the potential of targeting these components for the development of future therapeutic agents.

Original languageEnglish (US)
Pages (from-to)149-166
Number of pages18
JournalCancer Microenvironment
Volume3
Issue number1
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Tumor Microenvironment
Colorectal Neoplasms
Carcinogenesis
Neoplasms
Life Expectancy
Theoretical Models
Therapeutics
Epithelial Cells
Survival
Mortality

Keywords

  • Colon cancer
  • Extracellular matrix
  • Stroma
  • Tumor infiltrating cells
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The tumor microenvironment in colorectal carcinogenesis. / Peddareddigari, Vijay G.; Wang, Dingzhi; Dubois, Raymond N.

In: Cancer Microenvironment, Vol. 3, No. 1, 12.2010, p. 149-166.

Research output: Contribution to journalArticle

Peddareddigari, VG, Wang, D & Dubois, RN 2010, 'The tumor microenvironment in colorectal carcinogenesis', Cancer Microenvironment, vol. 3, no. 1, pp. 149-166. https://doi.org/10.1007/s12307-010-0038-3
Peddareddigari, Vijay G. ; Wang, Dingzhi ; Dubois, Raymond N. / The tumor microenvironment in colorectal carcinogenesis. In: Cancer Microenvironment. 2010 ; Vol. 3, No. 1. pp. 149-166.
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