The topopyrones poison human DNA topoisomerases I and II

Qasim A. Khan; Mark A. Elban; Sidney Hecht

doi:10.1021/ja805421b

The topopyrones poison human DNA topoisomerases I and II

Qasim A. Khan, Mark A. Elban, Sidney Hecht

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20 Scopus citations

Abstract

(Chemical Equation Presented) The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.

Original language	English (US)
Pages (from-to)	12888-12889
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	39
DOIs	https://doi.org/10.1021/ja805421b
State	Published - Oct 1 2008

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "(Chemical Equation Presented) The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.",

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N2 - (Chemical Equation Presented) The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.

AB - (Chemical Equation Presented) The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.

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The topopyrones poison human DNA topoisomerases I and II

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