The topopyrones poison human DNA topoisomerases I and II

Qasim A. Khan, Mark A. Elban, Sidney Hecht

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

(Chemical Equation Presented) The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical characterization. Presently it is shown that in addition to topoisomerase I, topopyrones A-D also act as poisons of human DNA topoisomerase II. The topopyrones thus represent a rare example of molecules capable of interacting effectively with more than one DNA topoisomerase.

Original languageEnglish (US)
Pages (from-to)12888-12889
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number39
DOIs
StatePublished - Oct 1 2008

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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