The TGF-beta family: signaling pathways, developmental roles, and tumor suppressor activities.

Aaron N. Johnson, Stuart Newfeld

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Intercellular communication is a critical process for all multicellular organisms, and communication among cells is required for proper embryonic development and adult physiology. Members of the Transforming Growth Factor-beta (TGF-beta) family of secreted proteins communicate information between cells via a complex signaling pathway, and family members are capable of inducing a wide range of cellular responses. The purpose of this review is to provide the reader with a broad introduction to our current understanding of three aspects of the TGF-beta family. These are the molecular mechanisms utilized by TGF-beta signaling pathways, the developmental roles played by TGF-beta family members in a variety of species, and the growing list of cancers in which various TGF-beta signaling pathways display tumor suppressor activity.

Original languageEnglish (US)
Pages (from-to)892-925
Number of pages34
JournalTheScientificWorldJournal
Volume2
DOIs
StatePublished - Apr 5 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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