The TGF-beta family

signaling pathways, developmental roles, and tumor suppressor activities.

Aaron N. Johnson, Stuart Newfeld

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Intercellular communication is a critical process for all multicellular organisms, and communication among cells is required for proper embryonic development and adult physiology. Members of the Transforming Growth Factor-beta (TGF-beta) family of secreted proteins communicate information between cells via a complex signaling pathway, and family members are capable of inducing a wide range of cellular responses. The purpose of this review is to provide the reader with a broad introduction to our current understanding of three aspects of the TGF-beta family. These are the molecular mechanisms utilized by TGF-beta signaling pathways, the developmental roles played by TGF-beta family members in a variety of species, and the growing list of cancers in which various TGF-beta signaling pathways display tumor suppressor activity.

Original languageEnglish (US)
Pages (from-to)892-925
Number of pages34
JournalTheScientificWorldJournal [electronic resource]
Volume2
StatePublished - Apr 5 2002

Fingerprint

tumor
Transforming Growth Factor beta
Tumors
Neoplasms
communication
Communication
Physiology
embryonic development
Cell Communication
Embryonic Development
physiology
cancer
family
protein
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

The TGF-beta family : signaling pathways, developmental roles, and tumor suppressor activities. / Johnson, Aaron N.; Newfeld, Stuart.

In: TheScientificWorldJournal [electronic resource], Vol. 2, 05.04.2002, p. 892-925.

Research output: Contribution to journalArticle

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