TY - JOUR
T1 - The TGF-beta family
T2 - signaling pathways, developmental roles, and tumor suppressor activities.
AU - Johnson, Aaron N.
AU - Newfeld, Stuart
PY - 2002/4/5
Y1 - 2002/4/5
N2 - Intercellular communication is a critical process for all multicellular organisms, and communication among cells is required for proper embryonic development and adult physiology. Members of the Transforming Growth Factor-beta (TGF-beta) family of secreted proteins communicate information between cells via a complex signaling pathway, and family members are capable of inducing a wide range of cellular responses. The purpose of this review is to provide the reader with a broad introduction to our current understanding of three aspects of the TGF-beta family. These are the molecular mechanisms utilized by TGF-beta signaling pathways, the developmental roles played by TGF-beta family members in a variety of species, and the growing list of cancers in which various TGF-beta signaling pathways display tumor suppressor activity.
AB - Intercellular communication is a critical process for all multicellular organisms, and communication among cells is required for proper embryonic development and adult physiology. Members of the Transforming Growth Factor-beta (TGF-beta) family of secreted proteins communicate information between cells via a complex signaling pathway, and family members are capable of inducing a wide range of cellular responses. The purpose of this review is to provide the reader with a broad introduction to our current understanding of three aspects of the TGF-beta family. These are the molecular mechanisms utilized by TGF-beta signaling pathways, the developmental roles played by TGF-beta family members in a variety of species, and the growing list of cancers in which various TGF-beta signaling pathways display tumor suppressor activity.
UR - http://www.scopus.com/inward/record.url?scp=0141544277&partnerID=8YFLogxK
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U2 - 10.1100/tsw.2002.178
DO - 10.1100/tsw.2002.178
M3 - Review article
C2 - 12805946
AN - SCOPUS:0141544277
SN - 2356-6140
VL - 2
SP - 892
EP - 925
JO - TheScientificWorldJournal
JF - TheScientificWorldJournal
ER -