The Telomerase Database

Joshua D. Podlevsky, Christopher J. Bley, Rebecca V. Omana, Xiaodong Qi, Julian Chen

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been studied intensively and components of the telomerase complex have been identified from over 160 eukaryotic species. In the last two decades, there has been a growing interest in studying telomerase owing to its vital role in chromosome stability and cellular immortality. To keep up with the remarkable explosion of knowledge about telomerase, we compiled information related to telomerase in an exhaustive database called the Telomerase Database http://telomerase.asu.edu/. The Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the phylogenetic relationship and structure, (iii) secondary structures of the RNA component and tertiary structures of various subunits of telomerase, (iv) mutations of telomerase components found in human patients and (v) active researchers who contributed to the wealth of current knowledge on telomerase. The information is hierarchically organized by the components, i.e. the telomerase reverse transcriptase (TERT), telomerase RNA (TR) and other telomerase-associated proteins. The Telomerase Database is a useful resource especially for researchers who are interested in investigating the structure, function, evolution and medical relevance of the telomerase enzyme.

Original languageEnglish (US)
JournalNucleic Acids Research
Volume36
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 2008

Fingerprint

Telomerase
Databases
Research Personnel
Chromosomal Instability
Ribonucleoproteins
Explosions
Sequence Alignment
Protein Subunits
Enzymes
Eukaryota

ASJC Scopus subject areas

  • Genetics

Cite this

Podlevsky, J. D., Bley, C. J., Omana, R. V., Qi, X., & Chen, J. (2008). The Telomerase Database. Nucleic Acids Research, 36(SUPPL. 1). https://doi.org/10.1093/nar/gkm700

The Telomerase Database. / Podlevsky, Joshua D.; Bley, Christopher J.; Omana, Rebecca V.; Qi, Xiaodong; Chen, Julian.

In: Nucleic Acids Research, Vol. 36, No. SUPPL. 1, 01.2008.

Research output: Contribution to journalArticle

Podlevsky, JD, Bley, CJ, Omana, RV, Qi, X & Chen, J 2008, 'The Telomerase Database', Nucleic Acids Research, vol. 36, no. SUPPL. 1. https://doi.org/10.1093/nar/gkm700
Podlevsky JD, Bley CJ, Omana RV, Qi X, Chen J. The Telomerase Database. Nucleic Acids Research. 2008 Jan;36(SUPPL. 1). https://doi.org/10.1093/nar/gkm700
Podlevsky, Joshua D. ; Bley, Christopher J. ; Omana, Rebecca V. ; Qi, Xiaodong ; Chen, Julian. / The Telomerase Database. In: Nucleic Acids Research. 2008 ; Vol. 36, No. SUPPL. 1.
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