The structure of bryostatin 2 from the marine bryozoan bugula neritina

George Pettit, Cherry L. Herald, Yoshiaki Kamano, Devens Gust, Reiko Aoyagi

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone lb.

Original languageEnglish (US)
Pages (from-to)528-531
Number of pages4
JournalJournal of Natural Products
Volume46
Issue number4
DOIs
StatePublished - Jul 1983

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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