The structure of bryostatin 2 from the marine bryozoan bugula neritina

George Pettit; Cherry L. Herald; Yoshiaki Kamano; Devens Gust; Reiko Aoyagi

doi:10.1021/np50028a017

The structure of bryostatin 2 from the marine bryozoan bugula neritina

George Pettit, Cherry L. Herald, Yoshiaki Kamano, Devens Gust, Reiko Aoyagi

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone lb.

Original language	English (US)
Pages (from-to)	528-531
Number of pages	4
Journal	Journal of Natural Products
Volume	46
Issue number	4
DOIs	https://doi.org/10.1021/np50028a017
State	Published - Jul 1983

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np50028a017

Cite this

@article{aded5f2aad244d5fa52c36f1ea032ed9,

title = "The structure of bryostatin 2 from the marine bryozoan bugula neritina",

abstract = "The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone lb.",

author = "George Pettit and Herald, {Cherry L.} and Yoshiaki Kamano and Devens Gust and Reiko Aoyagi",

year = "1983",

month = jul,

doi = "10.1021/np50028a017",

language = "English (US)",

volume = "46",

pages = "528--531",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - The structure of bryostatin 2 from the marine bryozoan bugula neritina

AU - Pettit, George

AU - Herald, Cherry L.

AU - Kamano, Yoshiaki

AU - Gust, Devens

AU - Aoyagi, Reiko

PY - 1983/7

Y1 - 1983/7

N2 - The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone lb.

AB - The marine Bryozoan Bugula neritina L. has been found to contain a new series (17) of related macrolides remarkably active against the murine P-388 lymphocytic leukemia. Based primarily upon high resolution (400 MHz) 1H-nmr studies, the second member of the series, bryostatin 2, has been shown to be the 20-membered ring lactone lb.

UR - http://www.scopus.com/inward/record.url?scp=0021060333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021060333&partnerID=8YFLogxK

U2 - 10.1021/np50028a017

DO - 10.1021/np50028a017

M3 - Article

AN - SCOPUS:0021060333

SN - 0163-3864

VL - 46

SP - 528

EP - 531

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

The structure of bryostatin 2 from the marine bryozoan bugula neritina

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this