The spread of tomato yellow leaf curl virus from the middle east to the world

Pierre Lefeuvre, Darren P. Martin, Gordon Harkins, Philippe Lemey, Alistair J A Gray, Sandra Meredith, Francisco Lakay, Adérito Monjane, Jean Michel Lett, Arvind Varsani, Jahangir Heydarnejad

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The ongoing global spread of Tomato yellow leaf curl virus (TYLCV; Genus Begomovirus, Family Geminiviridae) represents a serious looming threat to tomato production in all temperate parts of the world. Whereas determining where and when TYLCV movements have occurred could help curtail its spread and prevent future movements of related viruses, determining the consequences of past TYLCV movements could reveal the ecological and economic risks associated with similar viral invasions. Towards this end we applied Bayesian phylogeographic inference and recombination analyses to available TYLCV sequences (including those of 15 new Iranian full TYLCV genomes) and reconstructed a plausible history of TYLCV's diversification and movements throughout the world. In agreement with historical accounts, our results suggest that the first TYLCVs most probably arose somewhere in the Middle East between the 1930s and 1950s (with 95% highest probability density intervals 1905-1972) and that the global spread of TYLCV only began in the 1980s after the evolution of the TYLCV-Mld and -IL strains. Despite the global distribution of TYLCV we found no convincing evidence anywhere other than the Middle East and the Western Mediterranean of epidemiologically relevant TYLCV variants arising through recombination. Although the region around Iran is both the center of present day TYLCV diversity and the site of the most intensive ongoing TYLCV evolution, the evidence indicates that the region is epidemiologically isolated, which suggests that novel TYLCV variants found there are probably not direct global threats. We instead identify the Mediterranean basin as the main launch-pad of global TYLCV movements.

Original languageEnglish (US)
Article numbere1001164
JournalPLoS Pathogens
Volume6
Issue number10
DOIs
StatePublished - Oct 2010
Externally publishedYes

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Middle East
Lycopersicon esculentum
Genetic Recombination
Begomovirus
Geminiviridae
Viruses
Iran
Economics
Genome

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Lefeuvre, P., Martin, D. P., Harkins, G., Lemey, P., Gray, A. J. A., Meredith, S., ... Heydarnejad, J. (2010). The spread of tomato yellow leaf curl virus from the middle east to the world. PLoS Pathogens, 6(10), [e1001164]. https://doi.org/10.1371/journal.ppat.1001164

The spread of tomato yellow leaf curl virus from the middle east to the world. / Lefeuvre, Pierre; Martin, Darren P.; Harkins, Gordon; Lemey, Philippe; Gray, Alistair J A; Meredith, Sandra; Lakay, Francisco; Monjane, Adérito; Lett, Jean Michel; Varsani, Arvind; Heydarnejad, Jahangir.

In: PLoS Pathogens, Vol. 6, No. 10, e1001164, 10.2010.

Research output: Contribution to journalArticle

Lefeuvre, P, Martin, DP, Harkins, G, Lemey, P, Gray, AJA, Meredith, S, Lakay, F, Monjane, A, Lett, JM, Varsani, A & Heydarnejad, J 2010, 'The spread of tomato yellow leaf curl virus from the middle east to the world', PLoS Pathogens, vol. 6, no. 10, e1001164. https://doi.org/10.1371/journal.ppat.1001164
Lefeuvre P, Martin DP, Harkins G, Lemey P, Gray AJA, Meredith S et al. The spread of tomato yellow leaf curl virus from the middle east to the world. PLoS Pathogens. 2010 Oct;6(10). e1001164. https://doi.org/10.1371/journal.ppat.1001164
Lefeuvre, Pierre ; Martin, Darren P. ; Harkins, Gordon ; Lemey, Philippe ; Gray, Alistair J A ; Meredith, Sandra ; Lakay, Francisco ; Monjane, Adérito ; Lett, Jean Michel ; Varsani, Arvind ; Heydarnejad, Jahangir. / The spread of tomato yellow leaf curl virus from the middle east to the world. In: PLoS Pathogens. 2010 ; Vol. 6, No. 10.
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