The similarity index and DNA fingerprinting

Research output: Contribution to journalArticle

543 Scopus citations

Abstract

DNA-fingerprint similarity is being used increasingly to make inferences about levels of genetic variation within and between natural populations. It is shown that the similarity index-the average fraction of shared restriction fragments-provides upwardly biased estimates of population homozygosity but nearly unbiased estimates of the average identity-in-state for random pairs of individuals. A method is suggested for partitioning the DNA-fingerprint dissimilarity into within- and between-population components. Some simple expressions are given for the sampling variances of these estimators.

Original languageEnglish (US)
Pages (from-to)478-484
Number of pages7
JournalMolecular biology and evolution
Volume7
Issue number5
StatePublished - Oct 2 1990
Externally publishedYes

Keywords

  • DNA fingerprinting
  • population genetic analysis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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