The Sangre Por Salud Biobank

Facilitating Genetic Research in an Underrepresented Latino Community

Gabriel Shaibi, Davinder Singh, Eleanna De Filippis, Valentina Hernandez, Bill Rosenfeld, Essen Otu, Gregorio Montes de Oca, Sharon Levey, Carmen Radecki Breitkopf, Richard Sharp, Janet Olson, James Cerhan, Stephen Thibodeau, Erin Winkler, Lawrence Mandarino

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: The Sangre Por Salud (Blood for Health; SPS) Biobank was created for the purpose of expanding precision medicine research to include underrepresented Latino patients. It is the result of a unique collaboration between Mayo Clinic and Mountain Park Health Center, a federally qualified community health center in Phoenix, Arizona. This report describes the rationale, development, implementation, and characteristics of the SPS Biobank. Methods: Latino adults (ages 18-85 years) who were active patients within Mountain Park Health Center's internal medicine practice in Phoenix, Ariz., and had no history of diabetes were eligible. Participants provided a personal and family history of chronic disease, completed a sociodemographic, psychosocial, and behavioral questionnaire, underwent a comprehensive cardiometabolic risk assessment (anthropometrics, blood pressure and labs), and provided blood samples for banking. Laboratory results of cardiometabolic testing were returned to the participants and their providers through the electronic health record. Results: During the first 2 years of recruitment into the SPS Biobank, 2,335 patients were approached and 1,432 (61.3%) consented to participate; 1,354 (94.5%) ultimately completed all requisite questionnaires and medical evaluations. The cohort is primarily Spanish-speaking (72.9%), female (73.3%), with a mean age of 41.3 ± 12.5 years. Most participants were born outside of the US (77.9%) and do not have health insurance (77.5%). The prevalence of overweight (35.5%) and obesity (45.0%) was high, as was previously unidentified prediabetes (55.9%), type 2 diabetes (7.4%), prehypertension (46.8%), and hypertension (16.2%). The majority of participants rated their health as good to excellent (72.1%) and, as a whole, described their overall quality of life as high (7.9/10). Conclusion: Collaborative efforts such as the SPS Biobank are critical for ensuring that underrepresented minority populations are included in precision medicine initiatives and biomedical research that seeks to improve human health and reduce the burdens of disease.

Original languageEnglish (US)
JournalPublic Health Genomics
DOIs
StateAccepted/In press - Jul 5 2016

Fingerprint

Genetic Research
Hispanic Americans
Health
Precision Medicine
Prehypertension
Community Health Centers
Prediabetic State
Blood Banks
Electronic Health Records
Health Insurance
Internal Medicine
Type 2 Diabetes Mellitus
Biomedical Research
Chronic Disease
Obesity
Quality of Life
Blood Pressure
Hypertension
Research
Population

Keywords

  • Biobank
  • Bioethics
  • Community-based research
  • Health disparities
  • Hispanic populations
  • Latino

ASJC Scopus subject areas

  • Genetics(clinical)
  • Public Health, Environmental and Occupational Health

Cite this

Shaibi, G., Singh, D., De Filippis, E., Hernandez, V., Rosenfeld, B., Otu, E., ... Mandarino, L. (Accepted/In press). The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community. Public Health Genomics. https://doi.org/10.1159/000447347

The Sangre Por Salud Biobank : Facilitating Genetic Research in an Underrepresented Latino Community. / Shaibi, Gabriel; Singh, Davinder; De Filippis, Eleanna; Hernandez, Valentina; Rosenfeld, Bill; Otu, Essen; Montes de Oca, Gregorio; Levey, Sharon; Radecki Breitkopf, Carmen; Sharp, Richard; Olson, Janet; Cerhan, James; Thibodeau, Stephen; Winkler, Erin; Mandarino, Lawrence.

In: Public Health Genomics, 05.07.2016.

Research output: Contribution to journalArticle

Shaibi, G, Singh, D, De Filippis, E, Hernandez, V, Rosenfeld, B, Otu, E, Montes de Oca, G, Levey, S, Radecki Breitkopf, C, Sharp, R, Olson, J, Cerhan, J, Thibodeau, S, Winkler, E & Mandarino, L 2016, 'The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community', Public Health Genomics. https://doi.org/10.1159/000447347
Shaibi, Gabriel ; Singh, Davinder ; De Filippis, Eleanna ; Hernandez, Valentina ; Rosenfeld, Bill ; Otu, Essen ; Montes de Oca, Gregorio ; Levey, Sharon ; Radecki Breitkopf, Carmen ; Sharp, Richard ; Olson, Janet ; Cerhan, James ; Thibodeau, Stephen ; Winkler, Erin ; Mandarino, Lawrence. / The Sangre Por Salud Biobank : Facilitating Genetic Research in an Underrepresented Latino Community. In: Public Health Genomics. 2016.
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abstract = "Background/Aims: The Sangre Por Salud (Blood for Health; SPS) Biobank was created for the purpose of expanding precision medicine research to include underrepresented Latino patients. It is the result of a unique collaboration between Mayo Clinic and Mountain Park Health Center, a federally qualified community health center in Phoenix, Arizona. This report describes the rationale, development, implementation, and characteristics of the SPS Biobank. Methods: Latino adults (ages 18-85 years) who were active patients within Mountain Park Health Center's internal medicine practice in Phoenix, Ariz., and had no history of diabetes were eligible. Participants provided a personal and family history of chronic disease, completed a sociodemographic, psychosocial, and behavioral questionnaire, underwent a comprehensive cardiometabolic risk assessment (anthropometrics, blood pressure and labs), and provided blood samples for banking. Laboratory results of cardiometabolic testing were returned to the participants and their providers through the electronic health record. Results: During the first 2 years of recruitment into the SPS Biobank, 2,335 patients were approached and 1,432 (61.3{\%}) consented to participate; 1,354 (94.5{\%}) ultimately completed all requisite questionnaires and medical evaluations. The cohort is primarily Spanish-speaking (72.9{\%}), female (73.3{\%}), with a mean age of 41.3 ± 12.5 years. Most participants were born outside of the US (77.9{\%}) and do not have health insurance (77.5{\%}). The prevalence of overweight (35.5{\%}) and obesity (45.0{\%}) was high, as was previously unidentified prediabetes (55.9{\%}), type 2 diabetes (7.4{\%}), prehypertension (46.8{\%}), and hypertension (16.2{\%}). The majority of participants rated their health as good to excellent (72.1{\%}) and, as a whole, described their overall quality of life as high (7.9/10). Conclusion: Collaborative efforts such as the SPS Biobank are critical for ensuring that underrepresented minority populations are included in precision medicine initiatives and biomedical research that seeks to improve human health and reduce the burdens of disease.",
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