TY - JOUR
T1 - The route less taken
T2 - Pulmonary models of enteric Gram-negative infection
AU - Fisher, Michael L.
AU - Sun, Wei
AU - Curtiss, Roy
PY - 2014/3
Y1 - 2014/3
N2 - Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram-negative bacteria are host-restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host-pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram-negative bacteria relative to naturally occurring lung pathogens.
AB - Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram-negative bacteria are host-restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host-pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram-negative bacteria relative to naturally occurring lung pathogens.
KW - Gram-negative pathogens
KW - Respiratory/lung infection
UR - http://www.scopus.com/inward/record.url?scp=84902243261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902243261&partnerID=8YFLogxK
U2 - 10.1111/2049-632X.12109
DO - 10.1111/2049-632X.12109
M3 - Short survey
C2 - 24259516
AN - SCOPUS:84902243261
SN - 2049-632X
VL - 70
SP - 99
EP - 109
JO - Pathogens and Disease
JF - Pathogens and Disease
IS - 2
ER -