The route less taken: Pulmonary models of enteric Gram-negative infection

Michael L. Fisher, Wei Sun, Roy Curtiss

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram-negative bacteria are host-restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host-pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram-negative bacteria relative to naturally occurring lung pathogens.

Original languageEnglish (US)
Pages (from-to)99-109
Number of pages11
JournalPathogens and Disease
Volume70
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • Gram-negative pathogens
  • Respiratory/lung infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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