The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

Juliana D. Lindenau, Francisco M. Salzano, Ana Hurtado, Kim Hill, Mara H. Hutz

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.

    Original languageEnglish (US)
    JournalHuman Immunology
    DOIs
    StateAccepted/In press - Mar 2 2016

    Fingerprint

    North American Indians
    Skin Tests
    Immune System
    Tuberculosis
    Population
    Genes
    Tuberculin
    Toll-Like Receptor 9
    Complement C1
    Complement Receptors
    Mortality

    Keywords

    • Amerindians
    • CR1
    • Innate immunity
    • TLR9
    • Tuberculosis

    ASJC Scopus subject areas

    • Immunology
    • Immunology and Allergy

    Cite this

    The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population. / Lindenau, Juliana D.; Salzano, Francisco M.; Hurtado, Ana; Hill, Kim; Hutz, Mara H.

    In: Human Immunology, 02.03.2016.

    Research output: Contribution to journalArticle

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