The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population

Juliana D. Lindenau, Francisco M. Salzano, Ana Hurtado, Kim Hill, Mara H. Hutz

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Native American populations show higher tuberculosis (TB) mortality and infectivity rates than non-Native populations. Variants in the innate immune system seem to have an important role on TB susceptibility. The role of some innate immune system variants in TB susceptibility and/or skin test response (PPD) were investigated in the Aché, a Native American population. Complement receptor 1 and toll like receptor 9 variants were associated with anergy to PPD and protection to TB, respectively. These findings demonstrate an important role of the innate immune system variants in TB susceptibility.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Mar 2 2016

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Keywords

  • Amerindians
  • CR1
  • Innate immunity
  • TLR9
  • Tuberculosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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