The Role of the Microbiome in Cancer Initiation and Progression: How Microbes and Cancer Cells Utilize Excess Energy and Promote One Another’s Growth

Research output: Contribution to journalReview article

Abstract

Purpose of Review: We use an ecological lens to understand how microbes and cancer cells coevolve inside the ecosystems of our bodies. We describe how microbe-cancer cell interactions contribute to cancer progression, including cooperation between microbes and cancer cells. We discuss the role of the immune system in preventing this apparent ‘collusion’ and describe how microbe-cancer cell interactions lead to opportunities and challenges in treating cancer. Recent Findings: Microbiota influence many aspects of our health including our cancer risk. Since both microbes and cancer cells rely on incoming resources for their survival and replication, excess energy and nutrient input from the host can play a role in cancer initiation and progression. Summary: Certain microbes enhance cancer cell fitness by promoting proliferation and protecting cancer cells from the immune system. How diet influences these interactions remains largely unknown but recent evidence suggests a role for nutrients across the cancer continuum.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalCurrent Nutrition Reports
Volume8
Issue number1
DOIs
StatePublished - Mar 1 2019

Fingerprint

Microbiota
microorganisms
neoplasms
energy
Growth
Neoplasms
immune system
Cell Communication
nutrients
microbiome
neoplasm cells
Lens
Immune System
Food
ecosystems
Lenses
Ecosystem
diet
Diet

Keywords

  • Caloric restriction
  • Cancer
  • Cell proliferation
  • Diet
  • Ecology
  • Immune system
  • Inflammation
  • Metastasis
  • Microbe
  • Microbiome
  • Microbiota
  • Neoplasms
  • Neoplastic processes
  • Nutrition
  • Western diet

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "The Role of the Microbiome in Cancer Initiation and Progression: How Microbes and Cancer Cells Utilize Excess Energy and Promote One Another’s Growth",
abstract = "Purpose of Review: We use an ecological lens to understand how microbes and cancer cells coevolve inside the ecosystems of our bodies. We describe how microbe-cancer cell interactions contribute to cancer progression, including cooperation between microbes and cancer cells. We discuss the role of the immune system in preventing this apparent ‘collusion’ and describe how microbe-cancer cell interactions lead to opportunities and challenges in treating cancer. Recent Findings: Microbiota influence many aspects of our health including our cancer risk. Since both microbes and cancer cells rely on incoming resources for their survival and replication, excess energy and nutrient input from the host can play a role in cancer initiation and progression. Summary: Certain microbes enhance cancer cell fitness by promoting proliferation and protecting cancer cells from the immune system. How diet influences these interactions remains largely unknown but recent evidence suggests a role for nutrients across the cancer continuum.",
keywords = "Caloric restriction, Cancer, Cell proliferation, Diet, Ecology, Immune system, Inflammation, Metastasis, Microbe, Microbiome, Microbiota, Neoplasms, Neoplastic processes, Nutrition, Western diet",
author = "Corrie Whisner and Aktipis, {C Athena}",
year = "2019",
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doi = "10.1007/s13668-019-0257-2",
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journal = "Current Nutrition Reports",
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T2 - How Microbes and Cancer Cells Utilize Excess Energy and Promote One Another’s Growth

AU - Whisner, Corrie

AU - Aktipis, C Athena

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Purpose of Review: We use an ecological lens to understand how microbes and cancer cells coevolve inside the ecosystems of our bodies. We describe how microbe-cancer cell interactions contribute to cancer progression, including cooperation between microbes and cancer cells. We discuss the role of the immune system in preventing this apparent ‘collusion’ and describe how microbe-cancer cell interactions lead to opportunities and challenges in treating cancer. Recent Findings: Microbiota influence many aspects of our health including our cancer risk. Since both microbes and cancer cells rely on incoming resources for their survival and replication, excess energy and nutrient input from the host can play a role in cancer initiation and progression. Summary: Certain microbes enhance cancer cell fitness by promoting proliferation and protecting cancer cells from the immune system. How diet influences these interactions remains largely unknown but recent evidence suggests a role for nutrients across the cancer continuum.

AB - Purpose of Review: We use an ecological lens to understand how microbes and cancer cells coevolve inside the ecosystems of our bodies. We describe how microbe-cancer cell interactions contribute to cancer progression, including cooperation between microbes and cancer cells. We discuss the role of the immune system in preventing this apparent ‘collusion’ and describe how microbe-cancer cell interactions lead to opportunities and challenges in treating cancer. Recent Findings: Microbiota influence many aspects of our health including our cancer risk. Since both microbes and cancer cells rely on incoming resources for their survival and replication, excess energy and nutrient input from the host can play a role in cancer initiation and progression. Summary: Certain microbes enhance cancer cell fitness by promoting proliferation and protecting cancer cells from the immune system. How diet influences these interactions remains largely unknown but recent evidence suggests a role for nutrients across the cancer continuum.

KW - Caloric restriction

KW - Cancer

KW - Cell proliferation

KW - Diet

KW - Ecology

KW - Immune system

KW - Inflammation

KW - Metastasis

KW - Microbe

KW - Microbiome

KW - Microbiota

KW - Neoplasms

KW - Neoplastic processes

KW - Nutrition

KW - Western diet

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DO - 10.1007/s13668-019-0257-2

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JO - Current Nutrition Reports

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