The role of solvent in protein folding and in aggregation

Sara Vaiana, M. Manno, A. Emanuele, M. B. Palma-Vittorelli, M. U. Palma

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We discuss features of the effect of solvent on protein folding and aggregation, highlighting the physics related to the particulate nature and the peculiar structure of the aqueous solvent, and the biological significance of interactions between solvent and proteins. To this purpose we use a generalized energy landscape of extended dimensionality. A closer look at the properties of solvent induced interactions and forces proves useful for understanding the physical grounds of 'ad hoc' interactions and for devising realistic ways of accounting for solvent effects. The solvent has long been known to be a crucially important part of biological systems, and times appear mature for it to be adequately accounted for in the protein folding problem. Use of the extended dimensionality energy landscape helps eliciting the possibility of coupling among conformational changes and aggregation, such as proved by experimental data in the literature.

Original languageEnglish (US)
Pages (from-to)133-145
Number of pages13
JournalJournal of Biological Physics
Volume27
Issue number2-3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Protein Folding
folding
proteins
Physics
interactions
particulates
physics
energy
Proteins

Keywords

  • Computational modeling
  • Energy landscapes
  • Hydration
  • Hydrophobic interactions
  • Protein aggregation
  • Protein conformational changes
  • Protein folding
  • Protein-solvent interactions
  • Spinodal and coexistence

ASJC Scopus subject areas

  • Biophysics

Cite this

Vaiana, S., Manno, M., Emanuele, A., Palma-Vittorelli, M. B., & Palma, M. U. (2001). The role of solvent in protein folding and in aggregation. Journal of Biological Physics, 27(2-3), 133-145. https://doi.org/10.1023/A:1013146530021

The role of solvent in protein folding and in aggregation. / Vaiana, Sara; Manno, M.; Emanuele, A.; Palma-Vittorelli, M. B.; Palma, M. U.

In: Journal of Biological Physics, Vol. 27, No. 2-3, 2001, p. 133-145.

Research output: Contribution to journalArticle

Vaiana, S, Manno, M, Emanuele, A, Palma-Vittorelli, MB & Palma, MU 2001, 'The role of solvent in protein folding and in aggregation', Journal of Biological Physics, vol. 27, no. 2-3, pp. 133-145. https://doi.org/10.1023/A:1013146530021
Vaiana, Sara ; Manno, M. ; Emanuele, A. ; Palma-Vittorelli, M. B. ; Palma, M. U. / The role of solvent in protein folding and in aggregation. In: Journal of Biological Physics. 2001 ; Vol. 27, No. 2-3. pp. 133-145.
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