The Role of Prostaglandin E2 in Tumor-Associated Immunosuppression

Dingzhi Wang, Raymond N. DuBois

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Tumor-associated inflammation can create an immunosuppressive microenvironment allowing tumor cells to escape immunosurveillance. Inhibiting immunosuppression remains one of the major challenges in cancer immunotherapy via checkpoint inhibitors. Recent preclinical data from the Reis e Sousa group may provide a strong rationale for developing new therapeutics to subvert tumor-induced immunosuppression via prostaglandin inhibition.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalTrends in Molecular Medicine
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

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