Abstract
Biologically-based cancer risk assessmsent relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue of dose a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 50-51 |
| Number of pages | 2 |
| Journal | Folia Histochemica et Cytobiologica |
| Volume | 39 |
| Issue number | SUPPL. 2 |
| State | Published - Jan 1 2001 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology