The role of mTOR signaling in Alzheimer disease

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The buildup of Abeta and tau is believed to directly cause or contribute to the progressive cognitive deficits characteristic of Alzheimer disease. However, the molecular pathways linking Abeta and tau accumulation to learning and memory deficits remain elusive. There is growing evidence that soluble forms of Abeta and tau can obstruct learning and memory by interfering with several signaling cascades. In this review, I will present data showing that the mammalian target of rapamycin (mTOR) may play a role in Abeta and tau induced neurodegeneration.

Original languageEnglish (US)
Pages (from-to)941-952
Number of pages12
JournalFrontiers in Bioscience - Scholar
Volume4 S
Issue number3
StatePublished - Jan 1 2012
Externally publishedYes

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Sirolimus
Alzheimer Disease
Learning
Data storage equipment
Memory Disorders

Keywords

  • Abeta
  • AD
  • Alzheimer's disease
  • Autophagy
  • Learning and memory
  • mTOR
  • Plaques
  • PS1
  • Rapamycin
  • Review
  • Tangles
  • Tau

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

The role of mTOR signaling in Alzheimer disease. / Oddo, Salvatore.

In: Frontiers in Bioscience - Scholar, Vol. 4 S, No. 3, 01.01.2012, p. 941-952.

Research output: Contribution to journalArticle

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