The role of genetic diversity in cancer

L. M F Merlo, Carlo Maley

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The role of genetic heterogeneity within neoplasms is increasingly recognized as important for understanding the dynamics of cancer progression, cancer stem cells, and therapeutic resistance, and there is interest in intratumoral heterogeneity measurements as potential biomarkers for risk stratification. In this issue of the JCI, Park et al. characterize this genetic diversity in carcinoma in situ and in invasive regions from 3 types of human breast cancers and lay the groundwork for translation of these measures to the clinic.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalJournal of Clinical Investigation
Volume120
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Genetic Heterogeneity
Neoplastic Stem Cells
Carcinoma in Situ
Neoplasms
Biomarkers
Therapeutics
Breast Cancer 3

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of genetic diversity in cancer. / Merlo, L. M F; Maley, Carlo.

In: Journal of Clinical Investigation, Vol. 120, No. 2, 01.02.2010, p. 401-403.

Research output: Contribution to journalArticle

Merlo, L. M F ; Maley, Carlo. / The role of genetic diversity in cancer. In: Journal of Clinical Investigation. 2010 ; Vol. 120, No. 2. pp. 401-403.
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