The role of genetic diversity in cancer

Lauren M.F. Merlo; Carlo C. Maley

doi:10.1172/JCI42088

The role of genetic diversity in cancer

Lauren M.F. Merlo, Carlo C. Maley

Research output: Contribution to journal › Comment/debate › peer-review

47 Scopus citations

Abstract

The role of genetic heterogeneity within neoplasms is increasingly recognized as important for understanding the dynamics of cancer progression, cancer stem cells, and therapeutic resistance, and there is interest in intratumoral heterogeneity measurements as potential biomarkers for risk stratification. In this issue of the JCI, Park et al. characterize this genetic diversity in carcinoma in situ and in invasive regions from 3 types of human breast cancers and lay the groundwork for translation of these measures to the clinic.

Original language	English (US)
Pages (from-to)	401-403
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	120
Issue number	2
DOIs	https://doi.org/10.1172/JCI42088
State	Published - Feb 1 2010
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1172/JCI42088

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The role of genetic diversity in cancer

Abstract

ASJC Scopus subject areas

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