TY - JOUR
T1 - The role of α-synuclein in Parkinson’s disease
T2 - Insights from animal models
AU - Maries, Eleonora
AU - Dass, Biplob
AU - Collier, Timothy J.
AU - Kordower, Jeffrey H.
AU - Steece-Collier, Kathy
PY - 2003/9
Y1 - 2003/9
N2 - The abnormal accumulations of fibrillar α-synuclein in Lewy bodies and the mutations in the gene for α-synuclein in familial forms of Parkinson's disease have led to the belief that this protein has a central role in a group of neurodegenerative diseases known as the synucleinopathies. Our understanding of the biology of α-synuclein has increased significantly since its discovery in 1997, and recently developed animal models of the synucleinopathies have contributed to this understanding. The information gleaned from animal models has the potential to provide a framework for continuing the development of rational therapeutic strategies.
AB - The abnormal accumulations of fibrillar α-synuclein in Lewy bodies and the mutations in the gene for α-synuclein in familial forms of Parkinson's disease have led to the belief that this protein has a central role in a group of neurodegenerative diseases known as the synucleinopathies. Our understanding of the biology of α-synuclein has increased significantly since its discovery in 1997, and recently developed animal models of the synucleinopathies have contributed to this understanding. The information gleaned from animal models has the potential to provide a framework for continuing the development of rational therapeutic strategies.
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U2 - 10.1038/nrn1199
DO - 10.1038/nrn1199
M3 - Article
C2 - 12951565
AN - SCOPUS:0141499226
SN - 1471-003X
VL - 4
SP - 727
EP - 738
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 9
ER -