The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans

Larissa L. Vassilieva, Michael Lynch

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

Spontaneous mutations were accumulated in 100 replicate lines of Caenorhabditis elegans over a period of ~50 generations. Periodic assays of these lines and comparison to a frozen control suggest that the deleterious mutation rate for typical life-history characters in this species is at least 0.05 per diploid genome per generation, with the average mutational effect on the order of 14% or less in the homozygous state and the average mutational heritability ~0.0034. While the average mutation rate per character and the average mutational heritability for this species are somewhat lower than previous estimates for Drosophila, these differences can be reconciled to a large extent when the biological differences between these species are taken into consideration.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalGenetics
Volume151
Issue number1
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans'. Together they form a unique fingerprint.

  • Cite this