The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans

Larissa L. Vassilieva, Michael Lynch

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Spontaneous mutations were accumulated in 100 replicate lines of Caenorhabditis elegans over a period of ~50 generations. Periodic assays of these lines and comparison to a frozen control suggest that the deleterious mutation rate for typical life-history characters in this species is at least 0.05 per diploid genome per generation, with the average mutational effect on the order of 14% or less in the homozygous state and the average mutational heritability ~0.0034. While the average mutation rate per character and the average mutational heritability for this species are somewhat lower than previous estimates for Drosophila, these differences can be reconciled to a large extent when the biological differences between these species are taken into consideration.

Original languageEnglish (US)
Pages (from-to)119-129
Number of pages11
JournalGenetics
Volume151
Issue number1
StatePublished - Jan 1 1999
Externally publishedYes

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Caenorhabditis elegans
Mutation Rate
Diploidy
Drosophila
Genome
Mutation
Life History Traits

ASJC Scopus subject areas

  • Genetics

Cite this

The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans. / Vassilieva, Larissa L.; Lynch, Michael.

In: Genetics, Vol. 151, No. 1, 01.01.1999, p. 119-129.

Research output: Contribution to journalArticle

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