The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate

Daniel J. Peart, Richard J. Kirk, Angela R. Hillman, Leigh A. Madden, Jason C. Siegler, Rebecca V. Vince

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg-1 body mass of sodium bicarbonate (NaHCO3) (BICARB), or a placebo of 0.045 g kg-1 body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO 3 is unlikely to be due to a decreased oxidative stress.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume113
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Alkalosis
  • Anaerobic exercise
  • HSP72
  • Oxidative stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Fingerprint Dive into the research topics of 'The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate'. Together they form a unique fingerprint.

Cite this