The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate

Daniel J. Peart; Richard J. Kirk; Angela R. Hillman; Leigh A. Madden; Jason C. Siegler; Rebecca V. Vince

doi:10.1007/s00421-012-2419-4

The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate

Daniel J. Peart, Richard J. Kirk, Angela R. Hillman, Leigh A. Madden, Jason C. Siegler, Rebecca V. Vince

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg^-1 body mass of sodium bicarbonate (NaHCO₃) (BICARB), or a placebo of 0.045 g kg^-1 body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO ₃ is unlikely to be due to a decreased oxidative stress.

Original language	English (US)
Pages (from-to)	127-134
Number of pages	8
Journal	European Journal of Applied Physiology
Volume	113
Issue number	1
DOIs	https://doi.org/10.1007/s00421-012-2419-4
State	Published - Jan 2013
Externally published	Yes

Keywords

Alkalosis
Anaerobic exercise
HSP72
Oxidative stress

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Public Health, Environmental and Occupational Health
Physiology (medical)

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10.1007/s00421-012-2419-4

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title = "The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate",

abstract = "The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg-1 body mass of sodium bicarbonate (NaHCO3) (BICARB), or a placebo of 0.045 g kg-1 body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO 3 is unlikely to be due to a decreased oxidative stress.",

keywords = "Alkalosis, Anaerobic exercise, HSP72, Oxidative stress",

author = "Peart, {Daniel J.} and Kirk, {Richard J.} and Hillman, {Angela R.} and Madden, {Leigh A.} and Siegler, {Jason C.} and Vince, {Rebecca V.}",

note = "Funding Information: Acknowledgments The authors wish to thank those who volunteered for the study, and declare there was no financial support for this research project. Additionally, we would like to thank Miss Bryna Chrismas for her assistance with pilot work and advice on statistical analysis. All subjects provided written informed consent in accordance with the departmental and university ethical procedures and following the principles outlined in the Declaration of Helsinki.",

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AU - Peart, Daniel J.

AU - Kirk, Richard J.

AU - Hillman, Angela R.

AU - Madden, Leigh A.

AU - Siegler, Jason C.

AU - Vince, Rebecca V.

N1 - Funding Information: Acknowledgments The authors wish to thank those who volunteered for the study, and declare there was no financial support for this research project. Additionally, we would like to thank Miss Bryna Chrismas for her assistance with pilot work and advice on statistical analysis. All subjects provided written informed consent in accordance with the departmental and university ethical procedures and following the principles outlined in the Declaration of Helsinki.

PY - 2013/1

Y1 - 2013/1

N2 - The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg-1 body mass of sodium bicarbonate (NaHCO3) (BICARB), or a placebo of 0.045 g kg-1 body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO 3 is unlikely to be due to a decreased oxidative stress.

AB - The purpose of this study was to investigate the effects of pre-exercise alkalosis on the physiological stress response to high-intensity exercise. Seven physically active males (age 22 ± 3 years, height 1.82 ± 0.06 m, mass 81.3 ± 8.4 kg and peak power output 300 ± 22 W) performed a repeated sprint cycle exercise following a dose of 0.3 g kg-1 body mass of sodium bicarbonate (NaHCO3) (BICARB), or a placebo of 0.045 g kg-1 body mass of sodium chloride (PLAC). Monocyte-expressed heat shock protein 72 (HSP72) and plasma thiobarbituric acid reactive substances (TBARS) were significantly attenuated in BICARB compared to PLAC (p = 0.04 and p = 0.039, respectively), however total anti-oxidant capacity, the ratio of oxidised to total glutathione, cortisol, interleukin 6 and interleukin 8 were not significantly induced by the exercise. In conclusion, monocyte-expressed HSP72 is significantly increased following high-intensity anaerobic exercise, and its attenuation following such exercise with the ingestion of NaHCO 3 is unlikely to be due to a decreased oxidative stress.

KW - Alkalosis

KW - Anaerobic exercise

KW - HSP72

KW - Oxidative stress

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The physiological stress response to high-intensity sprint exercise following the ingestion of sodium bicarbonate

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