The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4

Agriculture & Biology

• ubiquitin 67%
• protein domains 67%
• ligases 60%
• Human gammaherpesvirus 8 54%
• major histocompatibility complex 53%
• Poxviridae 42%
• Murid gammaherpesvirus 4 29%
• immune evasion 22%
• immunologic receptors 22%
• ubiquitination 19%
• endosomes 19%
• Herpesviridae 18%
• zinc finger motif 17%
• genome 17%
• lysosomes 16%
• genes 16%
• acidification 15%
• cells 14%
• T-lymphocytes 14%
• glycoproteins 13%
• lysine 12%
• tail 12%
• open reading frames 12%
• proteins 10%
• degradation 9%

Medicine & Life Sciences

• PHD Zinc Fingers 100%
• Ligases 67%
• Ubiquitin 62%
• Major Histocompatibility Complex 47%
• Poxviridae 42%
• Human Herpesvirus 8 39%
• Down-Regulation 32%
• Proteins 22%
• Protein Interaction Domains and Motifs 22%
• Ubiquitinated Proteins 22%
• Genome 21%
• Immune Evasion 19%
• Genes 18%
• Herpesviridae 17%
• Endosomes 17%
• Ubiquitination 16%
• Lysosomes 15%
• Lysine 15%
• Open Reading Frames 14%
• Glycoproteins 13%
• T-Lymphocytes 9%
• Membranes 9%
• In Vitro Techniques 6%