The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture

Kelly A. Tennant, Deanna L. Adkins, Nicole A. Donlan, Aaron L. Asay, Nagheme Thomas, Jeffrey Kleim, Theresa A. Jones

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

The organization of forelimb representation areas of the monkey, cat, and rat motor cortices has been studied in depth, but its characterization in the mouse lags far behind. We used intracortical microstimulation (ICMS) and cytoarchitectonics to characterize the general organization of the C57BL/6 mouse motor cortex, and the forelimb representation in more detail. We found that the forelimb region spans a large area of frontal cortex, bordered primarily by vibrissa, neck, shoulder, and hindlimb representations. It included a large caudal forelimb area, dominated by digit representation, and a small rostral forelimb area, containing elbow and wrist representations. When the entire motor cortex was mapped, the forelimb was found to be the largest movement representation, followed by head and hindlimb representations. The ICMS-defined motor cortex spanned cytoarchitecturally identified lateral agranular cortex (AGl) and also extended into medial agranular cortex. Forelimb and hindlimb representations extended into granular cortex in a region that also had cytoarchitectural characteristics of AGl, consistent with the primary motor-somatosensory overlap zone (OL) characterized in rats. Thus, the mouse motor cortex has homologies with the rat in having 2 forelimb representations and an OL but is distinct in the predominance of digit representations.

Original languageEnglish (US)
Pages (from-to)865-876
Number of pages12
JournalCerebral Cortex
Volume21
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Forelimb
Motor Cortex
Inbred C57BL Mouse
Hindlimb
Vibrissae
Frontal Lobe
Elbow
Wrist
Haplorhini
Cats
Neck
Head

Keywords

  • cytoarchitecture
  • forelimb representation
  • intracortical microstimulation
  • motor map
  • primary motor cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. / Tennant, Kelly A.; Adkins, Deanna L.; Donlan, Nicole A.; Asay, Aaron L.; Thomas, Nagheme; Kleim, Jeffrey; Jones, Theresa A.

In: Cerebral Cortex, Vol. 21, No. 4, 04.2011, p. 865-876.

Research output: Contribution to journalArticle

Tennant, Kelly A. ; Adkins, Deanna L. ; Donlan, Nicole A. ; Asay, Aaron L. ; Thomas, Nagheme ; Kleim, Jeffrey ; Jones, Theresa A. / The organization of the forelimb representation of the C57BL/6 mouse motor cortex as defined by intracortical microstimulation and cytoarchitecture. In: Cerebral Cortex. 2011 ; Vol. 21, No. 4. pp. 865-876.
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