The one-step pickering emulsion polymerization route for synthesizing organic-inorganic nanocomposite particles

Huan Ma; Mingxiang Luo; Sriya Sanyal; Kaushal Rege; Lenore Dai

doi:10.3390/ma3021186

The one-step pickering emulsion polymerization route for synthesizing organic-inorganic nanocomposite particles

Huan Ma, Mingxiang Luo, Sriya Sanyal, Kaushal Rege, Lenore Dai

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of "smart" composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.

Original language	English (US)
Pages (from-to)	1186-1202
Number of pages	17
Journal	Materials
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/ma3021186
State	Published - 2010

Keywords

Nanocomposite particles
Pickering emulsion polymerization
Temperature sensitivity

ASJC Scopus subject areas

General Materials Science

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10.3390/ma3021186

Cite this

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abstract = "Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of {"}smart{"} composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.",

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AU - Ma, Huan

AU - Luo, Mingxiang

AU - Sanyal, Sriya

AU - Rege, Kaushal

AU - Dai, Lenore

PY - 2010

Y1 - 2010

N2 - Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of "smart" composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.

AB - Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of "smart" composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.

KW - Nanocomposite particles

KW - Pickering emulsion polymerization

KW - Temperature sensitivity

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The one-step pickering emulsion polymerization route for synthesizing organic-inorganic nanocomposite particles

Abstract

Keywords

ASJC Scopus subject areas

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