The one-step pickering emulsion polymerization route for synthesizing organic-inorganic nanocomposite particles

Huan Ma, Mingxiang Luo, Sriya Sanyal, Kaushal Rege, Lenore Dai

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Polystyrene-silica core-shell nanocomposite particles are successfully prepared via one-step Pickering emulsion polymerization. Possible mechanisms of Pickering emulsion polymerization are addressed in the synthesis of polystyrene-silica nanocomposite particles using 2,2-azobis(2-methyl-N-(2-hydroxyethyl)propionamide (VA-086) and potassium persulfate (KPS) as the initiator. Motivated by potential applications of "smart" composite particles in controlled drug delivery, the one-step Pickering emulsion polymerization route is further applied to synthesize polystyrene/poly(N-isopropylacrylamide) (PNIPAAm)-silica core-shell nanoparticles with N-isopropylacrylamide incorporated into the core as a co-monomer. The polystyrene/PNIPAAm-silica composite nanoparticles are temperature sensitive and can be taken up by human prostate cancer (PC3-PSMA) cells.

Original languageEnglish (US)
Pages (from-to)1186-1202
Number of pages17
JournalMaterials
Volume3
Issue number2
DOIs
StatePublished - 2010

Keywords

  • Nanocomposite particles
  • Pickering emulsion polymerization
  • Temperature sensitivity

ASJC Scopus subject areas

  • Materials Science(all)

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