The Omnipresence of DYRK1A in Human Diseases

Estelle Deboever, Alessandra Fistrovich, Christopher Hulme, Travis Dunckley

Research output: Contribution to journalReview articlepeer-review

Abstract

The increasing population will challenge healthcare, particularly because the worldwide population has never been older. Therapeutic solutions to age-related disease will be increasingly critical. Kinases are key regulators of human health and represent promising therapeutic targets for novel drug candidates. The dual-specificity tyrosine-regulated kinase (DYRKs) family is of particular interest and, among them, DYRK1A has been implicated ubiquitously in varied human diseases. Herein, we focus on the characteristics of DYRK1A, its regulation and functional role in different human diseases, which leads us to an overview of future research on this protein of promising therapeutic potential.

Original languageEnglish (US)
Article number9355
JournalInternational journal of molecular sciences
Volume23
Issue number16
DOIs
StatePublished - Aug 2022

Keywords

  • DYRK1A
  • cancers
  • diabetes
  • heart diseases
  • neurodegenerative diseases
  • protein kinase
  • viral infections

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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