TY - JOUR
T1 - The need for practical insecticide-resistance guidelines to effectively inform mosquito-borne disease control programs
AU - Namias, Alice
AU - Jobe, Ndey Bassin
AU - Paaijmans, Krijn Petrus
AU - Huijben, Silvie
N1 - Funding Information:
This study was supported by the Spanish Ministry of Science and Innovation through the ‘Centro de Excelencia Severo Ochoa 2019–2023’ Program (CEX2018-000806-S) and the Generalitat de Catalu-nya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID). KP was supported by the Bill and Melinda Gates Foundation and Obra Social ‘la Caixa’ Partnership for the Elimination of Malaria in Southern Mozambique (OPP1115265). SH was supported by the Branco Weiss Fellowship – Society in Science. None of these funding sources played a role in the writing of the manuscript or the decision to submit it for publication.
Funding Information:
This study was supported by the Spanish Ministry of Science and Innovation through the ?Centro de Excelencia Severo Ochoa 2019?2023? Program (CEX2018-000806-S) and the Generalitat de Catalu-nya through the CERCA Program. CISM is supported by the Government of Mozambique and the Spanish Agency for International Development (AECID). KP was supported by the Bill and Melinda Gates Foundation and Obra Social ?la Caixa? Partnership for the Elimination of Malaria in Southern Mozambique (OPP1115265). SH was supported by the Branco Weiss Fellowship ? Society in Science. None of these funding sources played a role in the writing of the manuscript or the decision to submit it for publication.
Publisher Copyright:
© Namias et al.
PY - 2021
Y1 - 2021
N2 - Monitoring local mosquito populations for insecticide resistance is critical for effective vector-borne disease control. However, widely used phenotypic assays, which are designed to monitor the emergence and spread of insecticide resistance (technical resistance), do not translate well to the efficacy of vector control products to suppress mosquito numbers in the field (practical resistance). This is because standard testing conditions such as environmental conditions, exposure dose, and type of substrate differ dramatically from those experienced by mosquitoes under field conditions. In addition, field mosquitoes have considerably different physiological characteristics such as age and blood-feeding status. Beyond this, indirect impacts of insecticide resistance and/or exposure on mosquito longevity, pathogen development, host-seeking behavior, and blood-feeding success impact disease transmission. Given the limited number of active ingredients currently available and the observed discordance between resistance and disease transmission, we conclude that additional testing guidelines are needed to determine practical resistance—the efficacy of vector control tools under relevant local conditions— in order to obtain programmatic impact.
AB - Monitoring local mosquito populations for insecticide resistance is critical for effective vector-borne disease control. However, widely used phenotypic assays, which are designed to monitor the emergence and spread of insecticide resistance (technical resistance), do not translate well to the efficacy of vector control products to suppress mosquito numbers in the field (practical resistance). This is because standard testing conditions such as environmental conditions, exposure dose, and type of substrate differ dramatically from those experienced by mosquitoes under field conditions. In addition, field mosquitoes have considerably different physiological characteristics such as age and blood-feeding status. Beyond this, indirect impacts of insecticide resistance and/or exposure on mosquito longevity, pathogen development, host-seeking behavior, and blood-feeding success impact disease transmission. Given the limited number of active ingredients currently available and the observed discordance between resistance and disease transmission, we conclude that additional testing guidelines are needed to determine practical resistance—the efficacy of vector control tools under relevant local conditions— in order to obtain programmatic impact.
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U2 - 10.7554/ELIFE.65655
DO - 10.7554/ELIFE.65655
M3 - Review article
C2 - 34355693
AN - SCOPUS:85113692296
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e65655
ER -