Abstract
The evolutionary conserved WNT signaling pathway orchestrates numerous complex biological processes during development and is critical to the maintenance of tissue integrity and homeostasis in the adult. As it relates to the central nervous system, WNT signaling plays several roles as it relates to neurogenesis, synaptic formation, memory, and learning. Thus, dysfunction of this pathway is associated with multiple diseases and disorders, including several neurodegenerative disorders. Alzheimer’s disease (AD) is characterized by several pathologies, synaptic dysfunction, and cognitive decline. In this review, we will discuss the various epidemiological, clinical, and animal studies that demonstrate a precise link between aberrant WNT signaling and AD-associated pathologies. In turn, we will discuss the manner in which WNT signaling influences multiple molecular, biochemical, and cellular pathways upstream of these end-point pathologies. Finally, we will discuss how merging tools and technologies can be used to generate next generation cellular models to dissect the relationship between WNT signaling and AD.
| Original language | English (US) |
|---|---|
| Article number | 1204 |
| Journal | Cells |
| Volume | 12 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 2023 |
| Externally published | Yes |
Keywords
- Alzheimer’s disease
- WNT
- amyloid
- central nervous system
- inflammation
- synaptic function
- tau
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology