TY - JOUR
T1 - The molecular basis of colorectal carcinogenesis
AU - Shattuck-Brandt, Rebecca L.
AU - DuBois, Raymond N.
PY - 1999
Y1 - 1999
N2 - The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.
AB - The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0033031008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033031008&partnerID=8YFLogxK
U2 - 10.1097/00001574-199901000-00002
DO - 10.1097/00001574-199901000-00002
M3 - Review article
C2 - 17023910
AN - SCOPUS:0033031008
SN - 0267-1379
VL - 15
SP - 3
EP - 8
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 1
ER -