The molecular basis of colorectal carcinogenesis

Rebecca L. Shattuck-Brandt, Raymond N. DuBois

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume15
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

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APC Genes
DNA Mismatch Repair
Proto-Oncogenes
Tumor Suppressor Genes
Colorectal Neoplasms
Carcinogenesis
Carcinoma
Genes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The molecular basis of colorectal carcinogenesis. / Shattuck-Brandt, Rebecca L.; DuBois, Raymond N.

In: Current Opinion in Gastroenterology, Vol. 15, No. 1, 1999, p. 3-8.

Research output: Contribution to journalArticle

Shattuck-Brandt, Rebecca L. ; DuBois, Raymond N. / The molecular basis of colorectal carcinogenesis. In: Current Opinion in Gastroenterology. 1999 ; Vol. 15, No. 1. pp. 3-8.
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