The molecular basis of colorectal carcinogenesis

Rebecca L. Shattuck-Brandt, Raymond N. DuBois

    Research output: Contribution to journalReview articlepeer-review

    3 Scopus citations


    The development of colorectal neoplasms can be characterized by an ordered series of events that are referred to as the dysplasia-carcinoma sequence. These histologic changes occur as a result of genetic alterations in proto-oncogenes and tumor-suppressor genes. This review emphasizes important studies characterizing the role of four genes, APC, Cox-2, DCC/Smad4, and the mismatch repair genes, in colorectal carcinogenesis.

    Original languageEnglish (US)
    Pages (from-to)3-8
    Number of pages6
    JournalCurrent Opinion in Gastroenterology
    Issue number1
    StatePublished - Mar 1 1999

    ASJC Scopus subject areas

    • Gastroenterology


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