TY - JOUR
T1 - The mechanobiology of brain function
AU - Tyler, William J.
N1 - Funding Information:
W.J.T is supported by funds from a US Department of Defense grant from the US Army Research, Development, and Engineering Command (RDECOM W911NF-09-0431), a Defense Advanced Research Projects Agency Young Faculty Award (DARPA N66001-10-1-4032) and a McKnight Technological Innovation in Neuroscience Award.
PY - 2012/12
Y1 - 2012/12
N2 - All cells are influenced by mechanical forces. In the brain, force-generating and load-bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal signalling and plasticity. Although the functions of mechanosensitive proteins have been thoroughly described in classical sensory systems, the effects of endogenous mechanical energy on cellular function in the brain have received less attention, and many working models in neuroscience do not currently integrate principles of cellular mechanics. An understanding of cellular-mechanical concepts is essential to allow the integration of mechanobiology into ongoing studies of brain structure and function.
AB - All cells are influenced by mechanical forces. In the brain, force-generating and load-bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal signalling and plasticity. Although the functions of mechanosensitive proteins have been thoroughly described in classical sensory systems, the effects of endogenous mechanical energy on cellular function in the brain have received less attention, and many working models in neuroscience do not currently integrate principles of cellular mechanics. An understanding of cellular-mechanical concepts is essential to allow the integration of mechanobiology into ongoing studies of brain structure and function.
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U2 - 10.1038/nrn3383
DO - 10.1038/nrn3383
M3 - Review article
C2 - 23165263
AN - SCOPUS:84872019086
SN - 1471-003X
VL - 13
SP - 867
EP - 878
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 12
ER -