The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease

Joshua S. Talboom, Ramon Velazquez, Salvatore Oddo

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Age-dependent cognitive decline is a major debilitating event affecting even individuals who are otherwise healthy. Understanding the molecular basis underlying these changes may increase the healthspan of the elderly population. It may also reveal insights into the pathogenesis of numerous neurodegenerative disorders characterized by cognitive deficits, as aging is the major risk factor for most of these disorders. Alzheimer’s disease (AD), the most common neurodegenerative disorder, first manifests itself as deficits in encoding new memories. As AD progresses, these deficits spread to other cognitive domains that further debilitate the person before contributing to their demise. Suppression of the mammalian target of rapamycin (mTOR) increases healthspan and lifespan in several organisms. Numerous reports have linked alterations in mTOR signaling to age-dependent cognitive decline and the pathogenesis of AD. This review will discuss recent work highlighting the complex role of mTOR in cognitive aging and in the pathogenesis of AD.

Original languageEnglish (US)
Article number15008
Journalnpj Aging and Mechanisms of Disease
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Sirolimus
Alzheimer Disease
Neurodegenerative Diseases
Cognitive Aging
Population
Cognitive Dysfunction

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer’s disease. / Talboom, Joshua S.; Velazquez, Ramon; Oddo, Salvatore.

In: npj Aging and Mechanisms of Disease, Vol. 1, No. 1, 15008, 01.01.2015.

Research output: Contribution to journalReview article

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