@article{5a7313907a944f64a3fcc46e1ea13b2e,
title = "The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum",
abstract = "We sequenced and annotated the genomes of four P. vivax strains collected from disparate geographic locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability in this species. We observe approximately twice as much SNP diversity among these isolates as we do among a comparable collection of isolates of P. falciparum, a malaria-causing parasite that results in higher mortality. This indicates a distinct history of global colonization and/or a more stable demographic history for P. vivax relative to P. falciparum, which is thought to have undergone a recent population bottleneck. The SNP diversity, as well as additional microsatellite and gene family variability, suggests a capacity for greater functional variation in the global population of P. vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen.",
author = "Neafsey, {Daniel E.} and Kevin Galinsky and Jiang, {Rays H Y} and Lauren Young and Sykes, {Sean M.} and Sakina Saif and Sharvari Gujja and Goldberg, {Jonathan M.} and Sarah Young and Qiandong Zeng and Chapman, {Sin{\'e}ad B.} and Dash, {Aditya P.} and Anvikar, {Anupkumar R.} and Sutton, {Patrick L.} and Birren, {Bruce W.} and Escalante, {Ananias A.} and Barnwell, {John W.} and Carlton, {Jane M.}",
note = "Funding Information: This work has been funded, in whole or in part, by federal funds from the US National Institute of Allergy and Infectious Diseases (NIAID), the US National Institutes of Health (NIH) and the US Department of Health and Human Services, under contracts HHSN266200400001C and HHSN2722009000018C. We gratefully acknowledge the Indian Council of Medical Research for financial support of the Malaria Parasite Bank at the National Institute of Malaria Research, New Delhi, and the NIMR Director for providing all facilities. We thank the NIAID/National Human Genome Research Institute (NHGRI) Eukaryotic Pathogens and Disease Vectors Working Group and the Broad Institute Genome Sequencing Platform for Funding Information: significant contributions to this project. K.G. and L.Y. are supported by a Global Health Program grant from the Bill and Melinda Gates Foundation. A.A.E. is supported by a grant from the NIH (RO1GM084320), and J.M.C. and P.L.S. are supported by grant U19AI089676, an NIAID International Center of Excellence for Malaria Research. The content is soley the responsibility of the authors and does not necessarily represent the official views of the NIH.",
year = "2012",
month = sep,
doi = "10.1038/ng.2373",
language = "English (US)",
volume = "44",
pages = "1046--1050",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",
}