The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

Judith Polonsky, Zoïa Varon, H. Jacquemin, G. R. Pettit

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

Original languageEnglish (US)
Pages (from-to)1122-1123
Number of pages2
JournalExperientia
Volume34
Issue number9
DOIs
StatePublished - Sep 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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