The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

Judith Polonsky, Zoïa Varon, H. Jacquemin, G. R. Pettit

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

Original languageEnglish (US)
Pages (from-to)1122-1123
Number of pages2
JournalExperientia
Volume34
Issue number9
DOIs
StatePublished - Sep 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara'. Together they form a unique fingerprint.

Cite this