The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

Judith Polonsky; Zoïa Varon; H. Jacquemin; G. R. Pettit

doi:10.1007/BF01922904

The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

Judith Polonsky, Zoïa Varon, H. Jacquemin, G. R. Pettit

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Abstract

An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

Original language	English (US)
Pages (from-to)	1122-1123
Number of pages	2
Journal	Experientia
Volume	34
Issue number	9
DOIs	https://doi.org/10.1007/BF01922904
State	Published - Sep 1978
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara",

abstract = "An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.",

author = "Judith Polonsky and Zo{\"i}a Varon and H. Jacquemin and Pettit, {G. R.}",

year = "1978",

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AU - Polonsky, Judith

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AU - Jacquemin, H.

AU - Pettit, G. R.

PY - 1978/9

Y1 - 1978/9

N2 - An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

AB - An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.

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JF - Experientia

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The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara

Abstract

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