An investigation of the Guyana plant Simarouba amara Aubl. (Simaroubaceae) for antineoplastic quassinoids led to isolation and structural determination of the new quassinoids 2′-acetylglaucarubine (1a) and 13,18-dehydroglaucarubinone (2). The previously known 2′-acetylglaucarubinone (3a) and glaucarubinone (3b) were also obtained. The new quassinoid 2 was found significantly to inhibit growth of the murine lymphocytic leukemia P388.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)